research The Wound Microbiome
The document concludes that better understanding the wound microbiome can improve chronic wound care by preserving helpful bacteria and targeting harmful ones.
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research Fibroblast Heterogeneity in Healthy and Wounded Skin
Different types of fibroblasts exist in skin and understanding them can help improve wound healing and treat scars.
research More Than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis
COVID-19 can cause over 50 long-term symptoms, with fatigue and headache being the most common.
research Discovery of Clinically Approved Drugs Capable of Inhibiting SARS-CoV-2 In Vitro Infection Using a Phenotypic Screening Strategy and Network-Analysis to Predict Their Potential to Treat COVID-19
Four drugs were found that could potentially treat COVID-19 by inhibiting the virus in lab tests.
research An Open-Label Prospective Observational Study of Antiandrogen and Non-Antiandrogen Early Pharmacological Approaches in Females with Mild-to-Moderate COVID-19: The Pre-AndroCoV Female Trial
Early treatment improved COVID-19 outcomes, and spironolactone helped reduce risks in females with high androgen levels.
research The Microanatomy of Human Skin in Aging
Aging skin shows thinner layers, fewer hair follicles, and new biomarkers like increased space between cells and smaller sebaceous glands.
research Three-Dimensional Reconstructions of Mechanosensory End Organs Suggest a Unifying Mechanism Underlying Dynamic, Light Touch
Dynamic, light touch is sensed through a common mechanism involving Piezo2 channels in sensory axons.
research Proxalutamide Improves Inflammatory, Immunologic, and Thrombogenic Markers in Mild-to-Moderate COVID-19 Males and Females: An Exploratory Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial Early Antiandrogen Therapy with Proxalutamide
Proxalutamide improved blood markers related to inflammation, immune response, and clotting in COVID-19 patients, potentially reducing hospitalizations.
research Proxalutamide Reduces Hospitalization Rate in Mild-to-Moderate COVID-19 Female Patients: A Randomized Double-Blinded Placebo-Controlled Trial
Proxalutamide significantly lowered hospitalization rates in women with mild-to-moderate COVID-19.
research 5-Alpha-Reductase Inhibitors Reduce Remission Time of COVID-19: Results From a Randomized Double-Blind Placebo-Controlled Interventional Trial in 130 SARS-CoV-2 Positive Men
5-Alpha-Reductase inhibitors shorten COVID-19 recovery time in men.
research Protein Kinase C Is a Key Target for Attenuation of Leigh Syndrome by Rapamycin
Rapamycin may help treat Leigh syndrome by targeting protein kinase C.
research The BLMP-1 Transcription Factor Promotes Oscillatory Gene Expression to Achieve Timely Molting
BLMP-1 is important for regular molting and gene expression cycles in worms.
research Post-Acute COVID-19 Syndrome and Its Prolonged Effects: An Updated Systematic Review
Long-lasting COVID-19 symptoms like fatigue and breathing difficulties can persist for over 60 days, requiring ongoing care.
research Tactile Innervation Densities Across the Whole Body
The skin has about 230,000 touch-sensitive nerve fibers, with high concentrations in the hands and face.
research Impact of Anti-Androgen Therapies on COVID-19 Susceptibility: A Case-Control Study in Male Population from Two COVID-19 Regional Centers of Lombardy, Italy
Men taking 5-alpha reductase inhibitors for prostate issues may be less likely to experience severe COVID-19, but it doesn't prevent ICU admission or death.
research Defining the Transcriptional Signature of Esophageal-to-Skin Lineage Conversion
Adult esophageal cells can start to become like skin cells, with a key pathway influencing this change.
research Divergent Molecular Signatures of Regeneration and Fibrosis During Wound Repair
Disrupting YAP signaling in skin cells leads to scar-free healing directed by specific cell signals.
research DNN-DTIs: Improved Drug-Target Interactions Prediction Using XGBoost Feature Selection and Deep Neural Network
The DNN-DTIs method accurately predicts drug-target interactions and is useful for drug repositioning.
research Werewolf, There Wolf: Variants in Hairless Associated with Hypotrichia and Roaning in the Lykoi Cat Breed
The unique coat of lykoi cats is likely caused by new variants in the Hairless gene.
research Beta-Caryophyllene Enhances Wound Healing Through Multiple Routes
Beta-caryophyllene, found in essential oils, helps wounds heal better in multiple ways.
research MiR-29 Is an Important Driver of Aging-Related Phenotypes
miR-29 is a key factor that accelerates aging.
research Diverse Northern Asian and Jomon-Related Genetic Structure Discovered Among Socially Complex Three Kingdoms Period Gaya Region Koreans
The DNA of ancient Koreans from the Three Kingdoms period shows a mix of northern Chinese and Japanese-Jomon ancestry, revealing two distinct genetic groups.
research ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair
A special foam called EG7 PTK-UR helps heal skin wounds better than other similar materials, working as well as a top-rated product and better than a polyester foam.
research Non-Invasive Human Skin Transcriptome Analysis Using mRNA in Skin Surface Lipids
The conclusion is that analyzing RNA from skin oils is a promising way to understand skin diseases.
research Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness
Hairless mammals have genetic changes in both their protein-coding and regulatory sequences related to hair.
research The SYP123-VAMP727 SNARE Complex Is Involved in the Delivery of Inner Cell Wall Components to the Root Hair Shank in Arabidopsis
The SYP123-VAMP727 complex is important for transporting materials that harden the root hair shank in Arabidopsis.
research Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing
The Aligned membranes improved wound healing and hair growth with a better immune response in mice.
research Mapping the Molecular and Structural Specialization of the Skin Basement Membrane for Inter-Tissue Interactions
The skin's basement membrane is specially designed to support different types of connections between skin layers and hair follicles.
research MendelVar: Gene Prioritization at GWAS Loci Using Phenotypic Enrichment of Mendelian Disease Genes
MendelVar is a tool that helps identify important genes by combining GWAS data with Mendelian disease information.
research A Powerful Method for Pleiotropic Analysis Under Composite Null Hypothesis Identifies Novel Shared Loci Between Type 2 Diabetes and Prostate Cancer
The new method found new shared genetic areas linked to both Type 2 Diabetes and Prostate Cancer.