Application of Histamine Receptors H2R, H3R, and H4R, but Not H1R, in Dermatology

    September 2014 in “ International Journal of Dermatology and Venereology ”
    Linfang Yang, Yuping Cao, Ping Ma
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    TLDR Certain histamine receptors (H2R, H3R, H4R) have unique roles in treating skin diseases, with H2R helping with chronic urticaria and other conditions, H3R providing pain relief and allergy benefits, and H4R reducing inflammation and itchiness.
    The document from 9 years ago discussed the role of histamine receptors H2R, H3R, and H4R in various skin diseases. It highlighted that each receptor had unique biological effects and their ligands played different roles in skin disease applications. H2 receptor antagonists were primarily used in combination with H1 receptor antagonists to treat chronic urticaria and other conditions, and could also be used to treat skin warts, herpes zoster, simplex herpes, androgenic alopecia, and acne. H3 receptor ligands potentially had analgesic and anti-allergic effects. H4 receptor antagonists demonstrated anti-inflammatory and anti-itching effects in various inflammatory disease models.
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