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The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

High levels of testosterone and anti-Müllerian hormone before pregnancy are linked to a higher risk of newborns needing intensive care.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Different connective tissue disorders have unique symptoms and treatments, with varying outcomes and often require ongoing care from a specialist.

Skin symptoms can indicate endocrine disorders and have various treatments.

Alopecia areata in infants may be more common than previously thought.

Mice treatments didn't grow hair, a patient treatment may affect immune response, and people with hair loss often feel anxious or depressed.

Some skin tumors from hair follicles and glands can be linked to genetic syndromes and may be benign or malignant.

Hormones significantly affect skin health, with vitamin D playing a key role.

The document concludes that treatments like oral anti-androgens, minoxidil, and topical spironolactone can be effective for hair loss in men and women.

Cyclosporin doesn't stop hair loss.

Topical spironolactone effectively treats hair loss in women.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Postinflammatory hyperpigmentation causes dark skin patches and needs personalized treatment.

New treatments targeting specific genes show promise for treating keratin disorders.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.