Cutaneous Tumors of Pilar Origin with Associated Syndromes

October 2023 in “ Research Review ”

Muthu Venkat T

cutaneous tumors pilar origin hair follicles sebaceous glands benign neoplasms Trichoblastoma Pilomatricoma Trichilemmoma Trichofolliculoma Fibrofolliculoma malignant tumors Pilomatriceal carcinoma proliferating trichilemmal tumors follicular differentiation gene abnormalities skin tumors hair follicle tumors benign skin tumors malignant skin tumors

TLDR Some skin tumors from hair follicles and glands can be linked to genetic syndromes and may be benign or malignant.

The document discusses cutaneous tumors of pilar origin, which develop from skin appendages like hair follicles and sebaceous glands. These tumors can be benign or malignant and may be associated with genetic syndromes. Benign neoplasms include Trichoblastoma, Pilomatricoma, Trichilemmoma, Trichofolliculoma, and Fibrofolliculoma, while malignant ones include Pilomatriceal carcinoma and proliferating trichilemmal tumors. Malignant tumors are rare but can be locally aggressive with potential for nodal involvement and distant metastasis. The tumors are categorized based on follicular differentiation, and several syndromes linked to these tumors involve gene abnormalities.

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