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This study found that testosterone enhances insulin secretion in human pancreatic islets by being converted into DHT and E2, processes that are necessary for this effect.

In this case study, researchers observed that steroidogenesis from adrenal androgens in prostate cancer tissues may explain progression in a 74-year-old man with low circulating testosterone.

This review discusses the controversial cardiovascular safety and efficacy of subcutaneous testosterone therapy in postmenopausal women, noting that its long-term use appears safe, but CV risk assessments remain disputed.

This review discusses the effects of neuroactive testosterone metabolites on CNS functions and suggests their potential as therapeutic options for neurological disorders, but reports no new clinical results.

This article reviews the effects of combined oral contraceptives on skin conditions and suggests prescribing guidelines for women with acne, as it reports no new clinical results.

This review examines androgen status in male and female obesity and its influence on the metabolic syndrome, but reports no new clinical results.

This study observed that in cases of moderately severe male-pattern hirsutism, elevated free plasma androgen levels occur in 85% of patients, suggesting a subtle hyperandrogenic state as a common underlying factor.

This article discusses the challenges in diagnosing female androgen insufficiency syndrome due to unreliable testosterone measurement methods but notes symptom improvement with testosterone therapy, emphasizing the need for women-specific formulations and safety guidelines.

This review found that women with idiopathic hirsutism may have increased 5α-reductase activity, as indicated by elevated levels of a dihydrotestosterone-reduced metabolite, but more research is needed to confirm its clinical relevance as a biomarker.

This article discusses the role of dihydrotestosterone in human prostatic adenocarcinoma growth and suggests that 6-methyleneprogesterone could be used to inhibit DHT for treating hormone-responsive prostate cancer, without new clinical findings.

Hidradenitis suppurativa improves with antiandrogen therapy.

This review discusses the challenges in measuring testosterone for assessing androgen excess in women and emphasizes the importance of quality control in laboratory methods, but it reports no new clinical results.

This study developed a validated gas chromatography–tandem mass spectrometry assay to assess sex steroid hormones in cerebrospinal fluid, finding substantial levels of DHEA, androstenedione, and testosterone, with strong correlations to serum levels, providing insight into sex steroid dynamics in the human CNS.

This study found that treatment with leuprolide plus cyclic estrogen/progestin may lead to a faster and greater improvement in hirsutism compared to a standard oral contraceptive regimen.

This study found that women with acne had higher rates of hyperandrogenism and obesity, and higher androgen levels and BMI were linked to increased acne severity.

This article reviews androgenic disorders in women, such as PCOS, highlighting how understanding these conditions could improve their management, but it presents no new clinical findings.

This review discusses causes and treatments for hirsutism in women and reports no new clinical results.

This review examines ethosomal structures and their mechanisms as skin delivery systems, outlining preparation methods and applications but presents no new experimental findings.

This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.

This review examines the role of hormones in acne pathogenesis, the use of hormonal therapies for treatment, and the importance of contraceptive counseling during isotretinoin therapy, but reports no new clinical results.

This study suggests that DHT may have a less potent effect on the prostate compared to testosterone while maintaining safety and similar effects on erythropoiesis and lipids.

Dihydrotestosterone (DHT) mainly affects nearby cells, doesn't significantly change prostate hormonal environment or cancer risk, and doesn't play a main role in causing hair loss or acne. More research is needed on its effects on heart health, sexual function, and bone health.

This case report describes a Canadian Husky dog with sertolioma that exhibited dermatological symptoms and aggressive behavior, both of which improved significantly after surgery.

This paper reviews the role of androgens in human skin function and the challenges in developing treatments for androgen-associated disorders, reporting no new experimental results.

Female and male AGA are different diseases.

This study suggests that combining testosterone and letrozole may accelerate puberty in boys with constitutional delay by increasing serum androgen bioactivity and facilitating pubertal progression.

This study found that finasteride impaired object recognition memory and altered hippocampal dendritic structures in male 3xTg-AD mice, suggesting potential sex differences in Alzheimer's disease pathology.

This study found that finasteride treatment in men with benign prostate hyperplasia significantly altered steroid hormone profiles and may contribute to depressive symptoms by affecting neuroactive steroid levels.

This study found that higher levels of dihydrotestosterone in the parietal region of the scalp may correlate with the clinical presentation of androgenetic alopecia.

In this study of young women with menstrual cycle disorders, researchers found that the type and severity of skin conditions are linked to both androgen levels and local skin receptor expression, suggesting customized treatment strategies could enhance management.