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Skin changes can indicate starvation and nutritional deficiencies in anorexia nervosa.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

Jasmonic acid and its derivatives play important roles in plant health and have potential uses in medicine and agriculture.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

The normal human prostate does not significantly affect blood DHT levels.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Non-obese women with hair loss have higher heart disease risk.

Blocking DGAT1 reduces oil gland size in mice and dogs, but only mice experience hair loss.

Sweet potato shochu oil and its components may effectively promote hair growth.

Possible link between hair loss and metabolic syndrome, with RANTES as a potential clue.

Kolaviron and quercetin may help treat prostate issues.

Modified HDL can better deliver drugs and genes, potentially improving treatments and reducing side effects.

Retinoids are effective for skin conditions like severe acne and psoriasis but must be used with caution due to potential side effects and risks during pregnancy.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

Androgen deprivation therapy for prostate cancer can cause sexual, physical, and psychological side effects, and doctors should manage these carefully.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.