40 citations
,
January 2016 in “PLoS ONE” The study found that exposing Arbas Cashmere goats to a short photoperiod significantly increased cashmere production by extending the anagen phase of hair follicles, with gene expression changes identified as contributing factors.
40 citations
,
December 2012 in “PLoS ONE” This study found that selective deletion of Ctip2 in epidermal keratinocytes in adult mice leads to atopic dermatitis-like inflammation and suggests Ctip2 plays a crucial role in skin barrier maintenance and inflammatory regulation.
30 citations
,
April 2018 in “Experimental Dermatology” This review discusses the historical development and current challenges in in vitro hair follicle culture, highlighting a need for advanced models using cell lines and tissue engineering, and reports no new results.
29 citations
,
March 2010 in “Journal of Dermatological Science” This study found that Wnt3a increased beta-catenin signaling and upregulated specific genes in cultured human dermal papilla cells, enhancing their response to PGE2 and potentially aiding hair growth.
28 citations
,
July 2008 in “Developmental Biology” This study found that the loss of Smad4 in keratinocytes reduces Dsg4 expression via disrupted BMP signaling, contributing to hair follicle degeneration and alopecia.
26 citations
,
February 2011 in “Journal of Plastic Reconstructive and Aesthetic Surgery” Technique effectively treats deformities, achieves re-pigmentation, and releases scar contractures.
24 citations
,
November 2021 in “PLoS ONE” In this study, fractional laser treatment was observed to reverse age-related gene expression changes in skin and enhance dermal remodeling, further improved by multiple treatments.
23 citations
,
January 2021 in “Scientific Reports” In this study, hair follicle germs containing vascular endothelial cells showed improved hair regeneration and morphogenesis-related gene expression in mice, suggesting a promising strategy for hair regenerative medicine.
21 citations
,
June 2016 in “Genesis” This study identified a gene expression signature in mouse embryonic dermal fibroblasts that depends on Wnt/β-catenin activity, potentially influencing dermal fibroblast identity and function.
18 citations
,
February 2022 in “Cell Death Discovery” In this study, researchers found that hair follicle-derived mesenchymal stem cells, modified to overexpress extracellular matrix protein 1, significantly improved liver function and reduced liver damage in cirrhotic mice by inhibiting hepatic stellate cell activation and TGF-β/Smad signaling.
17 citations
,
February 2015 in “International Journal of Molecular Sciences” This study found that keratinocyte stem/progenitor cell-conditioned medium significantly enhanced hair growth in mice and increased the proliferation of human hair follicle cells.
17 citations
,
December 2002 in “Biochemical and biophysical research communications” This study reports on the biochemical characteristics of S100A3 protein in human hair cuticle, notably finding its N-terminal methionine is acetylated and has a slightly lower isoelectric point compared to the recombinant version.
13 citations
,
October 2012 in “InTech eBooks” Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.
11 citations
,
January 2022 in “Theranostics” In this study, Wnt4 was identified as a key factor in cardiac repair, where its regulation in cardiac fibroblasts improved cardiac function and revascularization following ischemic reperfusion injury.
11 citations
,
March 2021 in “Journal of Bioscience and Bioengineering” This study demonstrated that adding human adipose-derived stem cells to hair follicle germ-like aggregates significantly improved hair shaft generation in transplanted nude mice, suggesting a promising strategy for hair regenerative medicine.
10 citations
,
May 2007 in “Oncology Reports” This study found that increased metastatic ability in colorectal cancer in a rat model was linked to changes in expression of multiple genes, including TGF-beta, PDGFb, and Rho B.
6 citations
,
June 2024 in “Scientific Reports” This study introduced RoPod, a customizable tool for low-stress live imaging of Arabidopsis roots, which improves data reproducibility and provides new insights into plant autophagy by revealing detailed, cell type-specific responses to chemical modulators.
4 citations
,
October 2018 in “Cell Stem Cell” This study shows that differences in Hoxc gene expression in hair follicle mesenchyme along the body axis contribute to regional variations in mammalian hair growth.
4 citations
,
May 2017 in “Data in Brief” This study identified five potential molecular targets for future androgenetic alopecia therapy using genome-wide gene-expression investigations and bioinformatics analyses.
2 citations
,
January 2019 in “Medizinische Genetik” Among families with pediatric brain disease, this study identified over 200 novel genetic causes, revealing potential treatment points using drug repurposing or nutritional supplementation.
1 citations
,
April 2017 in “Journal of Investigative Dermatology” This study found that cilostazol promoted hair growth in human dermal papilla cells and mouse models, suggesting its potential as a therapeutic target for alopecia treatment.
1 citations
,
April 2009 in “The Proceedings of the International Plant Nutrition Colloquium XVI” This study found that phosphorus and nitrogen deprivation increased root hair length in Brassica carinata and induced the expression of certain P-responsive genes, such as LRR and PRP.
1 citations
,
October 2001 in “Journal of Wood Science” This study found that extracts from the fungus YL161, Agaricus blazei, and the bark of Camptotheca cuminata promoted dermal papilla cell growth more effectively than pentadecanoic acid, suggesting potential for stimulating hair growth.
April 2026 in “Microsystems & Nanoengineering” This study developed HA-gel-dex hydrogels with enhanced ECM-like properties and functionality, showing promise for 3D bioprinting, tissue repair, and as wound dressings due to improved cell interaction, cytocompatibility, antimicrobial synergy, and wound healing in mice compared to traditional ECM bio-inks.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that conditional deletion of Mof in mice resulted in severe defects in skin development, including compromised epidermal differentiation and hair growth, leading to perinatal lethality.
September 2022 in “Institutional Repositories DataBase (IRDB)” 3D-oxy exosomes may significantly boost hair growth, offering new treatment options for hair loss.
January 2021 in “Research Square (Research Square)” This study mapped copy number variations in Chinese fine-wool sheep, identifying regions linked to important traits like milk production and growth, and highlighting a strong selection signal at the RXFP2 gene.
September 2020 in “Research Square (Research Square)” This study identified 21 candidate genes related to immunoglobulin concentrations in colostrum and serum of dairy cattle, which may aid in genetic improvement for disease resistance.
July 2020 in “Research Square (Research Square)” This study identified 21 candidate genes linked to immunoglobulin levels in colostrum and serum of dairy cattle, suggesting potential for genetic selection to enhance immunity.
June 2020 in “Annals of the Rheumatic Diseases” This observational study concluded that anti-Ku antibodies do not specifically indicate any systemic autoimmune disease or associated clinical phenotype.