This study found a significant discordance between clinical symptoms and dermatoscopic signs with histopathological inflammation in patients with LPP and AFF, affecting diagnostic and therapeutic approaches.
June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study provides evidence that innate lymphoid cells-type 1 can induce alopecia areata in human hair follicles, challenging the view that it is solely a CD8+ T cell-driven autoimmune disease.
January 2022 in “International Journal of Science and Research (IJSR)” This review discusses the biochemical and psychological impacts of polycystic ovary syndrome on immune functions against COVID-19 but reports no new clinical results.
This study found that Nubian ibex have developed genetic adaptations in response to their desert environment, including enhanced skin barrier, DNA repair, viral response, and metabolism of toxic compounds.
April 2021 in “Journal of Investigative Dermatology” This study suggests that rather than inhibiting IL-15, selectively stimulating IL-15Ra-mediated signaling could be beneficial for managing alopecia areata and possibly other inflammatory hair loss conditions, as IL-15 promoted hair growth and maintained immune privilege in human hair follicles.
April 2021 in “Journal of Investigative Dermatology” This study found that CD1a-restricted CD4+ T cells responsive to lysyl-phosphatidylglycerol were more frequent in the blood of atopic dermatitis patients, suggesting a potential role in the disease's Th2-mediated pathology.
April 2021 in “Journal of Investigative Dermatology” This study found that multicomponent microarray patches for SARS-CoV-2 vaccination produced stronger immune responses and fewer side effects in mice compared to traditional intramuscular injection.
March 2021 in “Research Square (Research Square)” This study found that patients with RASopathies demonstrated lower levels of serum IgA and CD8 T cells compared to controls, potentially indicating an increased risk of developing autoimmune disorders.
March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that type 2 immunity, especially involving ILC2 cells, helps maintain skin homeostasis by regulating the proliferation and community stability of hair follicle epithelial cells in the presence of Demodex mites.
September 2020 in “Journal of Cutaneous Pathology” In this case study, a 69-year-old woman with pityriasis rubra pilaris developed a scarring alopecia with lichen-planopilaris-like features, which responded well to early treatment.
This study found that PRL-1-overexpressing PD-MSCs reduced adipogenesis in orbital fibroblasts from Graves' ophthalmopathy patients by secreting IGFBPs and modulating the FAK pathway.
June 2020 in “Annals of the Rheumatic Diseases” This observational study concluded that anti-Ku antibodies do not specifically indicate any systemic autoimmune disease or associated clinical phenotype.
This review discusses the dynamic behavior of immune cells in skin immune responses using intravital imaging in mice and reports no new clinical results.
July 2018 in “Elsevier eBooks” This article reviews the clinical presentation, diagnosis, and treatment options for discoid lupus erythematosus and reports no new clinical results.
February 2018 in “Egyptian Journal of Radiation Sciences and Applications” This study observed that Egyptian patients with discoid lupus erythematosus have significantly lower serum vitamin D3 and antioxidant levels compared to healthy controls, suggesting potential benefits of vitamin D3 and antioxidant supplementation.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study investigates whether lymphocytes from mice with secondary alopecia areata can effectively induce the disease in a C3H/HeH mouse model, similar to lymphocytes from mice with spontaneous disease.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that 71% of patients treated with the gamma-secretase inhibitor PF-03084014 for desmoid tumors experienced dermatologic side effects, such as follicular lesions and pruritic eruptions, which were managed with topical or systemic treatments.
July 2016 in “American Journal of Dermatopathology” The meeting showcased rare skin disease cases, highlighting the need for accurate diagnosis and treatment.
This section presents 70 multiple choice questions designed for haematology specialist trainees, covering complex clinical cases and their likely diagnoses, adverse events, and management advice.
This article presents a collection of 70 multiple choice questions designed to assist haematology and core medical trainees with diagnostic and management skills, but it provides no new clinical findings.
Lupus is a complex disease that requires personalized treatment because it varies greatly between individuals.
January 2014 in “Durham e-Theses (Durham University)” In this study, the activation of Notch1 signaling in keratinocytes was found to play a key role in recruiting immune cells and facilitating skin repair after injury.
December 2013 in “Research Portal (King's College London)” This article discusses the anatomical and biological aspects of hair follicle stem cells in the bulge region but reports no new research findings.
This study reported that high cholesterol levels were linked to increased prostate cancer risk, while selenium supplementation affected gene expression, suggesting nutritional and clinical factors might influence prostate cancer risk and biology.
December 2012 in “Journal of dermatological science” This study observed that Langerhans cells and melanocytes migrated to hair follicle sites during human embryogenesis, suggesting that Langerhans cells acquire immunoregulatory properties there.
May 2009 in “The American Journal of Dermatopathology” This abstract contains only journal subscription and informational content and does not present any research findings.
September 2004 in “Experimental dermatology” This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.
12 citations
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September 2022 in “Frontiers in Immunology” This study found that soluble CD83 (sCD83) accelerated chronic and hard-to-heal wound healing and improved inflammatory and pro-resolving cytokine profiles, suggesting potential for therapeutic use.
15 citations
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November 2022 in “Cell Death and Disease” In this study, the researchers identified CEP135 as a biomarker linked to poor sarcoma survival and suggested PLK1 as a potential therapeutic target for sarcoma patients with high CEP135 expression.
21 citations
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April 2008 in “Toxicologic Pathology” This study found that CI-1033 caused skin lesions in rats that resemble effects seen in humans receiving EGF receptor inhibitors, suggesting this animal model can help explore the mechanisms behind this cutaneous toxicity.