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BRL 7660, once studied for male contraception, showed promise as an acne treatment but was not developed further due to competing drugs.

Hair loss in women is often due to hereditary conditions or stress, and while treatments like minoxidil can help, diagnosis and management require medical guidance.

Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.

Hair transplantation is beneficial if the right patients are chosen and the procedure is done carefully.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

BMPs are crucial for hair growth and their decrease by androgens leads to hair loss.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

Testosterone therapy increases bone density in older men with low testosterone levels.

Some wound-healing cells can turn into fat cells around new hair growth in mice.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.