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GlossaryCaspase

enzymes that trigger cell death by cutting specific proteins

Caspases are a family of enzymes that play a crucial role in programmed cell death, also known as apoptosis. They act like molecular scissors, cutting specific proteins in the cell to trigger a cascade of events leading to cell dismantling and removal, which is essential for maintaining healthy tissue and organ function.

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Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

research Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

11 citations, October 2021 in “Stem Cell Research & Therapy”

Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.

Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

research Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

22 citations, March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

research Effects of Mesenchymal Stem Cell Therapy on Alopecia Areata in Cellular and Hair Follicle Organ Culture Models

16 citations, October 2018 in “Experimental Dermatology”

Mesenchymal stem cell therapy may help treat alopecia areata by promoting hair growth and reducing inflammation.

research Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

13 citations, February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research Hairless-Knockout Piglets Generated Using CRISPR/Cas9 Exhibit Abnormalities in Skin and Thymus

3 citations, January 2019 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu”

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

research Signaling Pathways in Hair Aging

November 2023 in “Frontiers in cell and developmental biology”

Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.

research The JAK/STAT Signaling Pathway: From Bench to Clinic

489 citations, November 2021 in “Signal Transduction and Targeted Therapy”

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

research Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis

23 citations, October 2021 in “Cell Stem Cell”

Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.

research Diabetes Mellitus Inhibits Hair Follicle Regeneration by Inducing Macrophage Reprogramming-Mediated Pyroptosis

September 2024 in “Journal of Inflammation Research”

Type 1 Diabetes prevents hair growth by causing cell death in hair follicles.

research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

59 citations, July 2015 in “Journal of Immunology”

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

research Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia

27 citations, July 2012 in “Dermatologic Surgery”

Higher caspase-1 levels found in balding scalps; reducing it may help treat hair loss.

research Distribution of Caspase-14 in Epidermis and Hair Follicles Is Evolutionarily Conserved Among Mammals

21 citations, September 2005 in “The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology/Anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology”

Caspase-14 is important for skin and hair development in all mammals.

research Caspases in Life and Death: Their Role in Head Formation

7 citations, January 2023 in “Frontiers in Cell and Developmental Biology”

Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.

research Non-Apoptotic Role for Caspase-7 in Hair Follicles and Surrounding Tissue

6 citations, August 2015 in “Journal of Molecular Histology”

Caspase-7 has functions in skin and hair that are not related to cell death.

research Expression of Apoptosis-Related Genes in the Mouse Skin During the First Postnatal Catagen Stage, Focused on Localization of Bnip3L and Caspase-12

4 citations, June 2015 in “Connective tissue research”

The research found changes in gene expression related to cell death in mouse skin that help understand hair follicle development and skin health.

Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

research Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

1 citations, October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products”

Ficus carica leaf extract may help treat melanoma by promoting cancer cell death without harming normal cells.

research NLRP1 Promotes Tumor Growth by Enhancing Inflammasome Activation and Suppressing Caspase-3 Activity in Human Melanoma

1 citations, April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis

28 citations, September 1998 in “Journal of Investigative Dermatology”

Two distinct caspases in human skin help with cell death and skin formation.

Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

research Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

January 2022 in “International Journal of Medical Sciences”

Cedrol may be an effective treatment for colorectal cancer.

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

21 citations, January 2002 in “Journal of Cutaneous Medicine and Surgery”

Finasteride affects hair growth by changing caspase and XIAP levels, potentially treating hair diseases.

research Cell Death by Cornification

375 citations, June 2013 in “Biochimica et biophysica acta. Molecular cell research”

Cornification is how skin cells die to form the protective outer layer of skin, hair, and nails.

research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells

58 citations, January 2006 in “Skin Pharmacology and Physiology”

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

research Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

46 citations, March 2019 in “Journal of Pineal Research”

Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.