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    Glossary Caspase

    enzymes that trigger cell death by cutting specific proteins

    Caspases are a family of enzymes that play a crucial role in programmed cell death, also known as apoptosis. They act like molecular scissors, cutting specific proteins in the cell to trigger a cascade of events leading to cell dismantling and removal, which is essential for maintaining healthy tissue and organ function.

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    1. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size Molecular Cell · 2018 · 90 citations
    2. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt International Journal of Oncology · 2012 · 83 citations
    3. The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice Journal of Immunology · 2015 · 59 citations
    4. Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis Journal of Investigative Dermatology · 1998 · 28 citations
    5. Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia Dermatologic Surgery · 2012 · 27 citations
    6. Distribution of caspase‐14 in epidermis and hair follicles is evolutionarily conserved among mammals 2005 · 21 citations
    7. The concealed side of caspases: beyond a killer of cells Cellular and Molecular Life Sciences · 2024 · 13 citations
    8. Exploring caspase functions in mouse models APOPTOSIS · 2024 · 8 citations
    9. Making the head: Caspases in life and death Frontiers in Cell and Developmental Biology · 2023 · 7 citations
    10. Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue Journal of Molecular Histology · 2015 · 6 citations
    11. Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata Biomolecules and Biomedicine · 2024 · 5 citations
    12. Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions The Journal of Cell Biology · 2024 · 4 citations
    13. Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12 Connective tissue research · 2015 · 4 citations
    14. Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series American Journal of Dermatopathology · 2023 · 2 citations
    15. Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade Jundishapur Journal of Natural Pharmaceutical Products · 2021 · 1 citations
    16. 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma Journal of Investigative Dermatology · 2016 · 1 citations
    17. Shen-Ying-Yang-Zhen formula promotes angiogenesis around hair follicles, alleviates oxidative stress, and inhibits hair follicle apoptosis through the VEGF/Akt/Caspase-9 signaling axis Phytomedicine · 2025
    18. Platelet-rich plasma improves caspase-3 of skin graft treated with Tilapia Mozambique bio-dressing Open Veterinary Journal · 2025
    19. Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development Archives of Dermatological Research · 2013 · 19 citations
    20. Cedrol restricts the growth of colorectal cancer <i>in vitro</i> and<i> in vivo</i> by inducing cell cycle arrest and caspase-dependent apoptotic cell death International Journal of Medical Sciences · 2022
    21. Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle Stem Cell Research & Therapy · 2021 · 11 citations
    22. Cell death by cornification Biochimica et biophysica acta. Molecular cell research · 2013 · 375 citations
    23. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo andIn Vitro Journal of Investigative Dermatology · 1998 · 140 citations
    24. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006 · 58 citations
    25. Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation Experimental Dermatology · 2019 · 51 citations
    26. Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis Journal of Pineal Research · 2019 · 46 citations
    27. Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen) ˜The œAmerican journal of pathology · 2006 · 43 citations
    28. Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease Frontiers in immunology · 2020 · 41 citations
    29. Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/Fas L-Mediated Apoptotic Signaling PloS one · 2014 · 29 citations
    30. Ginsenoside Rb1 retards aging process by regulating cell cycle, apoptotic pathway and metabolism of aging mice Journal of ethnopharmacology · 2020 · 28 citations