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GlossaryCaspase-3

enzyme that plays a key role in programmed cell death

Caspase-3 is a crucial enzyme in the process of apoptosis, which is the programmed cell death that helps maintain healthy tissue by removing damaged or unnecessary cells. Often referred to as the "executioner" caspase, it plays a key role in dismantling cellular components during apoptosis, ensuring that cells die in a controlled manner without causing harm to surrounding tissues.

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Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

research Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

1 citations, October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products”

Ficus carica leaf extract may help treat melanoma by promoting cancer cell death without harming normal cells.

research NLRP1 Promotes Tumor Growth by Enhancing Inflammasome Activation and Suppressing Caspase-3 Activity in Human Melanoma

1 citations, April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Photosensitized 2-Amino-3-Hydroxypyridine-Induced Mitochondrial Apoptosis via Smac/DIABLO in Human Skin Cells

10 citations, March 2016 in “Toxicology and applied pharmacology”

Using A132 hair dye with sunlight can cause skin damage and hair loss.

research Non-Apoptotic Role for Caspase-7 in Hair Follicles and Surrounding Tissue

6 citations, August 2015 in “Journal of Molecular Histology”

Caspase-7 has functions in skin and hair that are not related to cell death.

research Topical Olive Oil With Downregulation of Stress Factors Protects Mice Skin From Precarious 3600 MHz Electromagnetic Radiation

March 2020 in “The Egyptian Journal of Histology”

Topical olive oil protects mice skin from harmful electromagnetic radiation.

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

21 citations, January 2002 in “Journal of Cutaneous Medicine and Surgery”

Finasteride affects hair growth by changing caspase and XIAP levels, potentially treating hair diseases.

Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

research Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

46 citations, March 2019 in “Journal of Pineal Research”

Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.

research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

43 citations, December 2006 in “The American journal of pathology”

Edar signaling is crucial for controlling hair growth and regression.

research The Effect of Tripeptide-Copper Complex on Human Hair Growth In Vitro

39 citations, July 2007 in “Archives of Pharmacal Research”

A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.

research Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/FasL-Mediated Apoptotic Signaling

29 citations, March 2014 in “PloS one”

Astragaloside IV may help prevent hair loss by blocking a specific pathway that leads to cell death.

research Ginsenoside Rb1 Retards Aging Process by Regulating Cell Cycle, Apoptotic Pathway, and Metabolism of Aging Mice

28 citations, March 2020 in “Journal of ethnopharmacology”

Ginsenoside Rb1 slows down aging in mice by affecting cell growth, cell death, and metabolism.

research Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis

28 citations, September 1998 in “Journal of Investigative Dermatology”

Two distinct caspases in human skin help with cell death and skin formation.

research Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue Regeneration

25 citations, June 2021 in “Developmental Cell”

Dying cells can help with faster healing and new hair growth by releasing a growth-promoting molecule.

research Effects of Short-Term Finasteride on Apoptotic Factors and Androgen Receptors in Prostate Cancer Cells

25 citations, December 2008 in “The Journal of Urology”

Short-term finasteride treatment may lower some cell death factors in prostate cancer cells.

research Accelerated Senescence in Skin in a Murine Model of Radiation-Induced Multi-Organ Injury

19 citations, February 2017 in “Journal of radiation research”

High-dose radiation speeds up aging in skin stem cells.

research Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrest Growth of Gynecologic Cancers

16 citations, May 2020 in “Frontiers in pharmacology”

Minoxidil can stop the growth of ovarian cancer cells without harming the heart.

research Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

13 citations, September 2021 in “Current Issues in Molecular Biology”

Dexpanthenol helps human hair follicle cells grow by preventing aging and death, and by supporting growth signals.

research TGF-β and HSP70 Profiles During Transformation of Yak Hair Follicles from Anagen to Catagen Stage

10 citations, February 2019 in “Journal of cellular physiology”

TGF-β2 helps yak hair follicles enter the regression phase, while HSP70 tries to prevent it.

research Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis

10 citations, January 2016 in “Planta Medica”

Formononetin, found in red clover plants, can promote hair regrowth and reduce hair loss by preventing cell death.

research The Therapeutic Promise of Apoptosis

9 citations, March 2019 in “Science”

Blocking cell death in certain stem cells can improve wound healing and tissue regeneration.

research Caspases in Life and Death: Their Role in Head Formation

7 citations, January 2023 in “Frontiers in Cell and Developmental Biology”

Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.

research Progranulin, A Secreted Tumorigenesis And Dementia-Related Factor, Regulates Mouse Hair Growth

7 citations, December 2008 in “Journal of Dermatological Science”

Progranulin overexpression leads to shorter, thinner hair and increased cell death in mouse hair follicles.

research Endocrinology and Metabolism News, August 2005: Effects of Finasteride on Benign Prostatic Hyperplasia Tissues

6 citations, August 2005 in “The Journal of Clinical Endocrinology & Metabolism”

Finasteride causes temporary cell death in BPH tissues.

research TSPO Ligand Etifoxine Attenuates LPS-Induced Cognitive Dysfunction in Mice

5 citations, October 2020 in “Brain Research Bulletin”

Etifoxine, an anxiety drug, can lessen brain inflammation and cognitive issues in mice, partly by increasing production of protective brain steroids.

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

4 citations, January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research Vitamin A Regulates Dermal Papilla Cell Proliferation and Apoptosis Under Heat Stress via IGF1 and Wnt10b Signaling

2 citations, August 2023 in “Ecotoxicology and environmental safety”

Vitamin A helps rabbit skin cells grow and survive heat stress.

research Ethanol Extract of Asiasari Radix Preferentially Induces Apoptosis in G361 Human Melanoma Cells by Differential Regulation of p53

2 citations, August 2019 in “BMC Complementary and Alternative Medicine”

Asiasari radix extract may be a potential treatment for melanoma because it selectively triggers cell death in melanoma cells by affecting p53 regulation.