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The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Diagnosing PCOS in teenagers is challenging and should use strict criteria to avoid misdiagnosis and unnecessary worry.

High androgen levels in young women with PCOS are linked to higher blood pressure.

Myrtle has various health benefits and potential for medicine development.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Eating fewer calories, less sugar and refined carbs, and more low-glycemic and omega-3 rich foods can help manage PCOS symptoms.

Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Women with PCOS who have low SHBG are more likely to have low good cholesterol and metabolic syndrome.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

Mood stabilizers like lithium and anticonvulsants have side effects that can lead to patients stopping their medication, and managing these effects is important for treatment adherence.

Some medications can cause hair loss, but stopping the drug usually leads to recovery within 3 months.

Endocrine therapies for cancer significantly increase the risk of hair loss.

Premature graying of hair may suggest health issues and currently lacks effective treatments.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Brazilian women with PCOS and both menstrual irregularity and high male hormone levels have a higher chance of having metabolic syndrome.

People with lichen planus are more likely to have dyslipidemia, especially higher triglyceride levels.

Insulin resistance in women with PCOS can lead to serious health issues, but lifestyle changes and certain medications can help manage symptoms.

The document concludes that menopause should be seen as a natural part of aging and managed with personalized care and informed choices.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.