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17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Spironolactone did not make hair thinner in women with excess hair growth.

PCOS may increase the risk of certain cancers.

PCOS is linked to a higher risk of endometrial cancer but not ovarian or breast cancer, and more research is needed on its role in cancer development and treatment effects.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Spironolactone reduced hair thickness and some testosterone levels in women with excessive hair growth.

Women are more likely to have long-term post-COVID symptoms than men.

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.

The research found that measuring androgens in urine can give extra information about body metabolism and is linked to androgen levels in the blood, especially in young girls.

Birth control pills slightly increase the risk of breast cancer, especially if used before the first full-term pregnancy.

Different treatments for PCOS focus on the specific symptoms, with weight loss and lifestyle changes being important.

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Neurosteroids show promise for treating epilepsy and more research is needed.

Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.

Androstanediol glucuronide is a reliable marker for hirsutism in women.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.