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Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Antiandrogens are somewhat effective in reducing excessive hair growth in women.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

Testosterone's muscle-building effects do not require its conversion to DHT.

New treatments for Alopecia Areata show promise but need to be more effective and affordable.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

Lower SHBG levels may increase the risk of PCOS.

Eating fewer calories, less sugar and refined carbs, and more low-glycemic and omega-3 rich foods can help manage PCOS symptoms.

Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.

Hair mineral analysis might help diagnose diseases early, but standard methods are needed.

A new gene, JMJD1C, may affect testosterone levels in men.

Testosterone with or without finasteride doesn't improve thinking skills in older men with low testosterone.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Women with acromegaly often have irregular periods due to hormone imbalances and growth hormone effects.