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Hair loss in African American women, caused by hair care, genetics, and environment, needs more research for better treatment.

Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Dermatologists need to understand hair products to treat hair and scalp issues better.

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

Hair and wool have complex microscopic structures with microfibrils and varying cystine content.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

Finasteride effectively blocks enzyme causing male pattern baldness.

Silver nanoparticles coated with substances like PEG showed strong antibacterial effects and improved wound healing when used in hydrogels.

PEVs improve minoxidil skin penetration, increasing hair growth.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.