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The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

9-cis-retinoic acid showed some effectiveness in treating AIDS-related Kaposi sarcoma but had significant side effects at higher doses.

Different small areas within hair follicles send specific signals that control what type of cells stem cells become.

Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.

Testosterone can help premenopausal and postmenopausal women with low sexual desire, but its long-term safety is unclear and it's not widely approved for this use.

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

The study concluded that the new wound model can be used to evaluate skin regeneration and nerve growth.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Norwegian puffin dogs have a unique type of hair loss that often doesn't get better on its own and responds well to ciclosporin treatment.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

Minoxidil controls blood pressure effectively, but may cause side effects like hypertrichosis.

Injection lipolysis effectively reduces small fat deposits and should be done with care and proper patient selection.

Autoimmune diseases can cause hair loss, and early treatment is important to prevent permanent damage.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

The study introduced a new imaging technology to track skin healing and bone marrow cell activity over time.

The document concludes that stem cell inactivity is actively controlled and important for tissue repair and balance.

Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.

Bald thigh syndrome in sighthounds is caused by structural defects in hair shafts due to downregulated genes and proteins.

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

Traditional Chinese medicine techniques like catgut embedment, moxibustion, and bloodletting showed better results for treating hair loss than the drug finasteride.

People in Jeddah know about Vitamin D and its sources but are unclear on how much they need daily, and while many women take supplements, attitudes towards increasing Vitamin D levels vary.

Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.

Linagliptin slows down premature aging in certain mice.

Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Cat claws stay sharp by shedding their outer layer through microcracks formed during activities.

When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.