40 citations
,
August 2018 in “Skin appendage disorders” This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.
33 citations
,
December 1982 in “Developmental Medicine & Child Neurology” The authors reviewed cases of six children with both hair-shaft abnormalities and neurological disorders, noting that such hair defects may indicate neurological conditions, including potentially treatable metabolic errors.
31 citations
,
September 2010 in “Current Opinion in Clinical Nutrition & Metabolic Care” This review discusses the lack of specific micronutrient supplementation recommendations for hair loss in patients on long-term parenteral nutrition and reports no new clinical results.
31 citations
,
December 1997 in “Developmental Medicine & Child Neurology” This case report describes a 5-year-old girl with biotinidase deficiency who had acute visual loss and gait disturbance but no typical symptoms, responding well to biotin therapy.
27 citations
,
September 2017 in “Journal of Medicinal Food” In this study, researchers found that a polyphenolic extract from Annurca apples, high in procyanidin B2, increased hair growth, density, and keratin content in healthy subjects after 2 months of use, and stimulated keratin biosynthesis in vitro.
19 citations
,
January 2011 in “Clinics” This article reviews alopecia areata incognita, a rare condition mostly seen in young women, and discusses its similarities and differences with telogen effluvium; however, it reports no new clinical findings.
19 citations
,
March 1988 in “International Journal of Dermatology” This paper reviews different types of hair shaft dysplasias and does not report any new clinical findings.
19 citations
,
November 1937 in “Experimental biology and medicine” This study reports that distinct scaly dermatoses in rats can be caused by deficiencies in vitamin H, vitamin B6, or lactoflavin, each preventable or treatable through nutritional adjustments.
16 citations
,
May 2009 in “Journal of child neurology” In this study, valproic acid treatment did not significantly affect serum biotinidase enzyme activity in children, but was associated with hair loss in some patients, which resolved with biotin supplementation.
15 citations
,
May 2006 in “Brain & development” The authors concluded that administering biotin may help prevent alopecia caused by reduced biotinidase activity during valproic acid therapy in rats.
14 citations
,
June 2016 in “Pediatric Dermatology” This review discusses the prognosis and treatment options for hair shaft disorders, finding no studies but suggesting some disorders improve with specific treatments like minoxidil and retinoids, while gentle hair care remains essential.
14 citations
,
April 2000 in “Animal Science/Animal science” This article explores how various nutrients and metabolic processes impact wool and hair follicle function in animals but reports no new experimental findings.
13 citations
,
July 2016 in “Pediatric Dermatology” This study found that loose anagen syndrome was more common in females and observed across all hair colors and skin types.
12 citations
,
September 2011 in “BMJ Case Reports” This case report describes a 2-month-old male with biotinidase deficiency whose seizures and skin symptoms improved dramatically with oral biotin supplementation.
11 citations
,
May 2009 in “Actas Dermo-Sifiliográficas” This review discusses various therapeutic options for alopecia areata and reports no new clinical results; treatments may manage symptoms but do not cure the condition.
10 citations
,
April 2020 in “Clinics in Dermatology” This case report describes a girl in China with biotinidase deficiency confirmed by genetic mutations, whose skin and hair symptoms improved with biotin therapy.
10 citations
,
July 2018 in “Our Dermatology Online” This research reviewed literature to evaluate the role of micronutrients in hair loss and hair growth, examining normal nutrient levels, their role in the hair follicle cycle, and their use in treatments, with data drawn from 92 peer-reviewed articles and reputable health organizations.
10 citations
,
January 2010 in “PubMed” This article reviews current hair loss treatments, proposing a hypothesis that a combination of drugs, supplements, and therapies may effectively manage hair loss, but presents no new clinical results.
10 citations
,
January 1992 in “Screening” This study concluded that newborn screening for biotinidase deficiency effectively identified cases and likely prevented irreversible complications from the disorder in some infants.
9 citations
,
June 2020 in “Animal genetics” In this study, researchers identified genetic variants in the PCCA and PRLR genes that are significantly associated with hair coat length in Brangus heifers, potentially contributing to more thermotolerant cattle.
9 citations
,
November 2014 in “Journal of Cutaneous Medicine and Surgery” This study found that a majority of dermatologists in Saudi Arabia believe in using vitamins and minerals to treat hair loss but emphasized the need for more research to confirm their effectiveness.
9 citations
,
July 2014 in “PubMed” This review examines the scientific evidence behind alternative treatments for female pattern hair loss and androgenetic alopecia, such as biotin, caffeine, and melatonin, but provides no new clinical results.
9 citations
,
February 1981 in “Australian journal of biological sciences” This study found that crossbred lambs fed liquid diets with reconstituted cow's milk initially grew wool without crimp, with crimp resuming two weeks post-weaning.
9 citations
,
October 1946 in “Experimental biology and medicine” This study reported that supplementation with inositol, biotin, cystine, or methionine prevented hair loss in rats fed soybean oil meal, with cystine and methionine also significantly increasing growth rates.
9 citations
,
February 1984 in “Zentralblatt für Veterinärmedizin Reihe A” This study found that feeding piglets high levels of egg white led to severe biotin deficiency, causing hair loss and brittle claws, highlighting biotin's role in maintaining healthy skin and claws.
8 citations
,
January 2017 in “Elsevier eBooks” This review discusses the use of nutraceuticals in dermatology for preventing and reversing signs of skin aging, but it reports no new clinical results.
8 citations
,
January 2009 in “Bulletin of the Veterinary Institute in Pulawy” This study reports a case of hair loss and skin changes in goats due to Scopulariopsis brevicaulis infection, successfully treated with itraconazole and D-biotin in a sick goat kid.
8 citations
,
September 1981 in “Zentralblatt für Veterinärmedizin Reihe A” In this animal study, pigs on a biotin-deficient diet showed significant hair loss, weak and brittle claws, and skin lesions after 8–10 weeks, with tissue necrosis observed microscopically after 15 weeks.
7 citations
,
May 2022 in “The Journal of Dermatology” This narrative review found that post-COVID-19 hair loss, particularly telogen effluvium, poses a significant mental and social burden, with minoxidil potentially aiding recovery, although more clinical research is needed to confirm its effectiveness.
7 citations
,
July 2021 in “PubMed” This review assesses the role of vitamins A, B, C, and D in treating dermatologic conditions and highlights promising applications, although further research is required to confirm their efficacy.