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    Glossary Biotin Deficiency

    lack of Vitamin B7 causing hair loss and skin issues

    Biotin deficiency, also known as Vitamin B7 deficiency, occurs when the body lacks sufficient biotin, a water-soluble B-vitamin essential for metabolizing fats, carbohydrates, and proteins. Symptoms can include hair loss, skin rashes, brittle nails, and neurological issues such as depression and lethargy. This condition can result from inadequate dietary intake, genetic disorders affecting biotin metabolism, or prolonged consumption of raw egg whites, which contain avidin, a protein that binds biotin and prevents its absorption.

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    1. Biotin and biotinidase deficiency Expert Review of Endocrinology & Metabolism · 2008 · 166 citations
    2. Biotin deficiency complicating parenteral alimentation: Diagnosis, metabolic repercussions, and treatment 1985 · 50 citations
    3. Biotin Deficiency in an Infant Fed with Amino Acid Formula The Journal of Dermatology · 2005 · 43 citations
    4. Biotin deficiency in an infant fed with amino acid formula and hypoallergenic rice Acta Paediatrica · 1996 · 29 citations
    5. Biotin Deficiency in a Patient with Short Bowel Syndrome during Home Parenteral Nutrition Journal of Parenteral and Enteral Nutrition · 1984 · 26 citations
    6. Acute and Chronic Biotin Deficiencies in the Monkey (Macaca Mulatta) Journal of Nutrition · 1945 · 21 citations
    7. Zinc and biotin deficiencies after pancreaticoduodenectomy. PubMed · 2010 · 11 citations
    8. Consumption of a low-carbohydrate and high-fat diet (the ketogenic diet) exaggerates biotin deficiency in mice Nutrition · 2013 · 10 citations
    9. Biotin Deficiency in Telogen Effluvium: Fact or Fiction? PubMed · 2020 · 2 citations
    10. Effect of Primary Biotin Deficiency on the Skin of Germ-Free and Conventional Mice Fed a Purified Biotin-Deficient Diet without Supplementation with Egg White. Journal of Clinical Biochemistry and Nutrition · 1997 · 2 citations
    11. Efficacy of Compound GV-350 with Tricofer® Iron, Cystine and Biotin in the Management of Telogen Effluvium in Women with Iron Deficiency 2025
    12. Alopecia and periorificial dermatitis in biotin-responsive multiple carboxylase deficiency Journal of the American Academy of Dermatology · 1983 · 55 citations
    13. Possible biotin deficiency in adults receiving long-term total parenteral nutrition American Journal of Clinical Nutrition · 1983 · 31 citations
    14. Dramatic Clinical Improvement With Biotin Mega‐Dose Therapy in a Neonate With Holocarboxylase Synthetase Deficiency Molecular Genetics & Genomic Medicine · 2024 · 2 citations
    15. Biotinidase Deficiency: Prevalence, Impact And Management Strategies. PubMed · 2020 · 89 citations
    16. Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice Cell Reports · 2017 · 82 citations
    17. Diet and hair loss: effects of nutrient deficiency and supplement use Dermatology practical & conceptual · 2017 · 79 citations
    18. Serum biotin levels in women complaining of hair loss International Journal of Trichology · 2016 · 71 citations
    19. Rethinking biotin therapy for hair, nail, and skin disorders Journal of the American Academy of Dermatology · 2018 · 57 citations
    20. Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame? Current Opinion in Clinical Nutrition & Metabolic Care · 2010 · 31 citations
    21. Hair Loss After Sleeve Gastrectomy and Effect of Biotin Supplements Journal of Laparoendoscopic & Advanced Surgical Techniques · 2020 · 13 citations
    22. Biotinidase deficiency characterized by skin and hair findings Clinics in Dermatology · 2020 · 10 citations
    23. Biotin Is Required for the Zinc Homeostasis in the Skin Nutrients · 2019 · 6 citations
    24. Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea Giornale italiano di dermatologia e venereologia · 2019 · 5 citations
    25. Changes in the Hydrophobic Proteins in Response to Biotin Administration in Serum of Infant Patients with Alopecia as Assessed by the Protein Micro-Sequencing Method Journal of microbial & biochemical technology · 2015 · 4 citations
    26. Development of a system for clinical evaluation of the biotin status of sows. PubMed · 1986 · 4 citations
    27. Biotin Elsevier eBooks · 2019 · 2 citations
    28. Low level of maternal biotin intake changes the expression of biotin transporter in dams and fetuses in mice 2014 · 2 citations
    29. Comment on the Use of Biotin for Hair Loss Skin appendage disorders · 2017 · 1 citations
    30. Deep Learning Based Non-Invasive Framework for Nutritional Deficiency Detection Using Hair and Nail Images FMDB Transactions on Sustainable Health Science Letters · 2026