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Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

The document concluded that certain compounds might strongly bind to and potentially inhibit a key SARS-CoV-2 protein, but further testing is needed.

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Hesperidin protects rat testicles from finasteride damage and improves sperm health.

Noni fruit extract, specifically the FEA-3 sub-fraction, can increase hair growth and reduce baldness in male rabbits, potentially acting like common hair loss treatments.

Phytoconstituents from Cyperus Rotundus may help treat hirsutism by interacting with the 5 α reductase enzyme.

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.

SHBG may be a useful early indicator and treatment target for PCOS.

The enzyme Rand protease works well for leather dehairing and its stability is important, with Leu75 playing a key role.

Removing part of the vitamin D receptor stops vitamin D from working properly.

The research explains how a human enzyme binds and processes its substrate, which could relate to its role in biological functions and hair loss.

Keratin from hair binds well to gold and BMP-2, useful for bone repair.

A synthetic octapeptide may help promote hair growth and counteract hair loss.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

Compounds from the Sansevieria trifasciata plant might be effective for treating hair loss.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Birth control pills help treat skin and hair growth problems linked to high male hormone levels.

Analog 23 is a promising compound for prostate cancer treatment.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

The chapter explains the causes of excessive hair growth and masculinization in women and how to measure hormone levels related to these conditions.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

RNA aptamers can specifically block FGF5-related cell growth, potentially treating related diseases or hair disorders.

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.