3 citations
,
September 2024 in “The FASEB Journal” This review discusses the roles of dermal white adipose tissue in skin functions and pathology, underscoring its antibacterial activity and potential anti-fibrotic role, but reports no new experimental results.
1 citations
,
April 2026 in “Cancer Nanotechnology” This review examines nanozymes as promising tools for cancer diagnosis and therapy due to their enzyme-mimicking catalytic properties and highlights their challenges, including biosafety and clinical translation, alongside potential improvements through biomimetic designs, particularly utilizing exosome-based strategies for targeted delivery to tumors.
December 2022 in “Dermatology and Therapy” This review discusses the unmet needs and barriers in managing alopecia areata in Latin America, highlighting access constraints and recommending coordinated efforts to improve patient outcomes with promising new treatments.
November 2022 in “Arab Gulf Journal of Scientific Research” This review discusses the potential clinical benefits and functional properties of taurine as a conditionally essential amino acid, noting its presence in energy drinks, but reports no new experimental results.
303 citations
,
October 2000 in “Nature” This study found that RXRα plays a critical role in hair cycling and keratinocyte functions in mice, likely through its interaction with VDR in epidermal cells.
181 citations
,
January 2019 in “Cell” In this research, authors found that skin-resident ILCs regulate sebaceous gland function and microbial balance, emphasizing an immune-epithelia system that supports host-microbe symbiosis.
44 citations
,
July 2016 in “Stem Cells Translational Medicine” This study demonstrated that cultured epidermal stem cells and skin-derived precursors can regenerate functional hair follicles and sebaceous glands in both mice and adult humans, suggesting potential for bioengineered skin substitutes.
33 citations
,
July 2021 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses the use of nanocarrier technology in functional cosmetics to enhance skin penetration, increase ingredient stability, and allow codelivery of active ingredients, without reporting new clinical results.
18 citations
,
September 2023 in “Experimental Dermatology” This review examines the role of skin microbes in enhancing the skin barrier and their involvement in skin diseases like atopic dermatitis, while also discussing current and future therapeutic strategies targeting the skin microbiome.
14 citations
,
May 2022 in “International Journal of Molecular Sciences” This study found that platelet-rich plasma therapy reduced inflammation and improved bladder function in a rat model of ketamine-induced ulcerative cystitis.
8 citations
,
July 2022 in “International Journal of Molecular Sciences” This review reports no new results but highlights the secretory function of keratinocytes, focusing on how various secretions, notably growth factors, impact stem cell differentiation into keratinocytes.
2 citations
,
May 2023 in “International Journal of Molecular Sciences” This review discusses current knowledge about the TRPV3 ion channel's role in skin functions and diseases, highlighting its potential as a therapeutic target for pain and itch, though suitable ligands are limited.
2 citations
,
September 2022 in “Frontiers in Immunology” This article reviews the emerging non-inflammatory roles of regulatory T cells in the skin and reports no new clinical findings, suggesting broad biological influence beyond traditional immune functions.
This review highlights the potential of 3D bioprinting in developing functional, patient-specific artificial skin, addressing limitations of traditional skin grafts and advancing regenerative medicine applications.
December 2025 in “Bioengineering” This review explains that dysregulated sebum secretion and composition contribute to acne and impaired skin barriers while highlighting factors like diet and hormones affecting sebaceous activity, and identifies novel molecular targets and model systems for future therapeutic developments.
18 citations
,
October 2021 in “Frontiers in Physiology” This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.
17 citations
,
February 2018 in “Journal of Investigative Dermatology” This study found that the PPAR-γ modulator N-acetyl-GED may enhance mitochondrial function in human hair follicles, particularly in outer root sheath keratinocytes.
10 citations
,
May 2020 in “Dermatology Research and Practice” This review discusses "follicular hypoglycania" as a potential pathology in hair growth disorders and reports that proteoglycan replacement therapy may improve hair loss treatments, though it presents no new clinical trial results.
3 citations
,
April 2025 in “Advanced Healthcare Materials” In this study, researchers developed hyaluronic acid derivatives functionalized with nitric oxide photodonors for light-activated skin treatments, finding that the compounds released NO under blue light and enhanced keratinocyte proliferation and migration, suggesting potential for therapeutic use.
3 citations
,
December 2018 in “Routledge eBooks” This chapter reviews the chemistry of keratin fibers, which are essential for understanding the structural stability and functionality of mammalian hair and other similar biological materials.
1 citations
,
March 2024 in “Science” In this study, researchers found that retinoic acid is crucial for hair follicle stem cell function and tissue regeneration by resolving lineage plasticity, with potential therapeutic implications for hair growth, wound healing, and cancer.
December 2025 in “International Journal of Molecular Sciences” This study found that an aqueous extract of Bacopa procumbens improved motor function and preserved neuronal structure in a mouse model of Parkinson's disease, suggesting its neuroprotective potential.
This review examines the role of vitamin D and its receptor in skin functions, exploring mechanisms regulating proliferation, differentiation, immunity, and tumor suppression, without reporting new research findings.
179 citations
,
June 2000 in “The American journal of pathology” This study reports that the asebia-2J mutation in mice affects sebaceous gland function and leads to hair follicle destruction, offering a model for human scarring alopecias.
140 citations
,
December 2017 in “Journal of Controlled Release” This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.
60 citations
,
May 2015 in “Archives of dermatological research” This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.
23 citations
,
June 2012 in “PLOS ONE” This study found that KLF4 expression in mouse hair follicle stem cells is important for effective cutaneous wound healing, with its knockdown leading to reduced stem cell populations and delayed healing.
7 citations
,
November 2023 in “Microorganisms” This study suggests that the intestinal microbiota may have protective effects against celiac disease by degrading gluten and maintaining intestinal barrier integrity, but disruptions in the microbiota can exacerbate the disease.
5 citations
,
January 2019 in “Elsevier eBooks” This chapter reviews skin components, wound healing mechanisms, and the potential of biomaterials to enhance skin repair and regeneration, without offering new experimental results.
May 2026 in “Frontiers in Cell and Developmental Biology” This review discusses hair follicle organoids as emerging models for studying hair biology and disorders, emphasizing their promise for bridging basic research and clinical applications, but reports no new results.