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This study explores the complex mechanisms of skin aging, including cellular senescence and disrupted communication, and highlights rejuvenation strategies like gene expression rewiring and microbiome modulation, offering potential frameworks for regenerative therapies and precise interventions in skin and systemic aging.

This source discusses how radiotherapy-induced skin fibrosis, a chronic side effect affecting cancer survivors' quality of life, is driven by ongoing inflammation and fibroblast activity, and emphasizes the need for comprehensive dermatologic management and better diagnostic tools.

This review discusses advancements in skin microphysiological systems, such as 3D bioprinting, skin organoids, and skin-on-a-chip, and their effectiveness in emulating human skin functions for research and preclinical applications, highlighting the potential for replacing animal testing with these innovative technologies.

This study highlights the critical role of mitochondria in skin aging and wound repair, suggesting that targeted interventions such as antioxidants, NAD⁺ boosters, and NRF2-based therapies may enhance mitochondrial function and improve cutaneous health.

Aging skin is affected by inflammation, reduced stem cell function, and slower wound healing.

This study suggests that mitochondrial dysfunction might contribute to the pathogenesis of Lichen planopilaris by triggering a metabolic shift that leads to chronic inflammation and hair follicle damage.

New materials and methods could improve skin healing and reduce scarring.

This review discusses the potential of electrospun gelatin-based nanofiber dressings for wound healing and skin regeneration, detailing their properties, enhanced functionalities through crosslinking and bioactive components, and their application in treating challenging wound types like burns and diabetic wounds.

This essay discusses the establishment, maintenance, and role of skin stem cells in tissue homeostasis, wound repair, and their relation to skin cancer, without reporting new experimental findings.

This review discusses the origins, differentiation, and function of dermal fibroblasts in skin development and healing, reporting no new clinical results.

This study found that long-term use of triterpenoids from Ganoderma lucidum may improve brain function and alleviate aging-related issues in normal and Alzheimer's mouse models.

This article reviews the anatomy and pathology of skin and hair to aid in diagnosing skin diseases and discusses potential therapies, without reporting new clinical results.

This review discusses the roles of store-operated Ca 2+ entry proteins in skin cell function and their links to various skin diseases, but it reports no new results.

This study found that using three-dimensional cell culture with Matrigel enhances the biological function and stemness of stem cells, leading to improved soft tissue repair and healing by activating the host microenvironment and autologous stem cells.

This chapter reviews traditional and tissue-engineered treatments for skin defects and discusses advances in bioengineered skin constructs, but it presents no new experimental results.

This study suggests that low-dose IL-2 and IL-15 may help restore immune tolerance in alopecia areata by maintaining Treg cell function, presenting a potential new treatment strategy.

This review summarizes the composition, bioactive functions, and potential industrial applications of rice bran polysaccharides, focusing on how extraction methods and modifications impact their biological activities.

This study examines the effects of excessive or prolonged exposure to blue light on retinal function and highlights its potential health implications, noting that both photoreceptor and intrinsically photosensitive retinal ganglion cells (ipRGCs) are particularly sensitive to blue wavelengths.

This study reports that in aged mice, hair follicle dermal stem cells exhibit diminished self-renewal and preferential differentiation into dermal sheath cells, contributing to age-related hair loss.

This article in Experimental Dermatology does not include an abstract or any new research findings.

This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.

This review discusses the role of regulatory T cells in skin, including their impact on hair follicle regeneration, wound healing, and immune tolerance, without presenting new clinical findings.

This article discusses the roles of epidermal stem cells in maintaining skin homeostasis and highlights how deregulation in signaling pathways may lead to cancer, but it reports no new experimental results.

This review discusses the advancements and challenges in developing in vitro human skin models incorporating components like vasculature for drug testing and disease research, but reports no new clinical results.

In this review, the authors highlighted the potential of natural polysaccharides from plants, animals, and microbes to modulate immune responses, reduce inflammation, and strengthen the intestinal barrier, suggesting their promising role as immunomodulatory agents in pharmaceutical applications.

This study suggests that the interaction between folliculin and plakophilin-4 (p0071) may play a role in folliculin's tumor suppressor function by regulating RhoA signaling, impacting cell migration and junction formation.

This review summarizes recent findings on keratins 6, 16, and 17, highlighting their role in keratinocyte behavior and nuclear functions, and discusses their potential as biomarkers for various skin pathologies, including damage, inflammation, and cancer, rather than in healthy skin.

This study found that Wnt7a-containing conditioned medium from UC-MSCs can accelerate wound healing and promote hair follicle regeneration by enhancing specific cellular functions in the wound microenvironment.

This study demonstrated that an engineered human skin equivalent can generate follicle-like structures resembling fetal skin, highlighting the role of the dermal compartment in directing epithelial cell fate in vitro.

This article reviews the role of polarity proteins in epidermal morphogenesis and homeostasis and discusses how their alteration may contribute to skin disease, but reports no new experimental findings.