November 2022 in “Journal of Investigative Dermatology” This study reports that activating the bitter taste receptor TAS2R4 with rebaudioside A can inhibit hair growth in human scalp hair follicles by promoting catagen through TGF-β pathway activation.
January 2018 in “The journal of the convergence on culture technology” This study observed that applying astringent persimmon fruit extract may significantly enhance hair growth and lengthen the hair in genetically balding Black mice.
148 citations
,
March 2022 in “The New England Journal of Medicine” In two phase 3 trials, this study found that oral baricitinib significantly improved hair regrowth compared to placebo in adults with severe alopecia areata after 36 weeks, though longer trials are needed to ascertain its long-term efficacy and safety.
1 citations
,
January 2014 This study found that Crataegus pinnatifida extract promoted hair growth in mice by inducing the anagen phase, potentially through activating signaling pathways that enhance cell survival.
21 citations
,
April 2019 in “Clinical, cosmetic and investigational dermatology” This article reviews the causes and clinical presentation of pseudofolliculitis barbae, highlighting how genetic susceptibility and hair removal practices contribute to its development, but reports no new research findings.
June 2026 in “Drugs & Therapy Perspectives” This study reports that patients with severe alopecia areata who experienced sustained scalp regrowth while receiving continuous baricitinib treatment showed improvements in health-related quality of life and reductions in anxiety and depression symptoms.
In this retrospective study, researchers found that baricitinib was effective for treating moderate to severe alopecia areata, with response rates in 24 patients comparable to existing real-world data, and no new safety concerns were identified.
March 2025 in “NATIONS UNIVERSITY INTERNATIONAL JOURNAL OF MULTI-DISCIPLINARY STUDIES” This case report highlights that Baricitinib led to significant hair regrowth and resolution of atopic dermatitis symptoms in a 22-year-old female with coexisting autoimmune conditions.
This study identified ISPP-Rb, a novel immuno-stimulatory complex from Royoporus badius, that significantly activates murine macrophage cells and induces multiple proinflammatory cytokines.
July 2022 in “Forte Journal” In this study, researchers tested hair tonic formulations with varying concentrations of bitter melon extract and found that higher concentrations enhanced hair growth in rabbits, with the 15% extract showing the greatest effect without causing skin irritation.
October 2025 in “Electronic Theses and Dissertations Repository (University of Pisa)” In this study, baricitinib treatment for severe alopecia areata was well tolerated, with minor metabolic changes and PLR emerging as a sensitive marker of treatment response.
October 2025 in “Journal of Clinical Medicine” This study found that in patients with severe alopecia areata, those who responded early to baricitinib treatment typically had a lower baseline Severity of Alopecia Tool score, shorter disease duration, and higher erythrocyte sedimentation rate, suggesting these factors may predict therapeutic success.
66 citations
,
June 2021 in “Journal of The American Academy of Dermatology” In this phase 2 study, baricitinib at 2 mg and 4 mg doses significantly improved hair regrowth in adults with alopecia areata and ≥50% scalp hair loss compared to placebo, without new safety concerns, although the small sample size limits the results' generalizability.
7 citations
,
January 2013 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study found that incorporating Argania spinosa kernel oil and/or Theobroma grandiflorum seed butter into hair care formulations reduced protein loss in Caucasian hair dyed with an oxidative product.
July 2024 in “Journal of Investigative Dermatology” This study suggests that macrophages, especially CD206+ subsets, play a key role in hair growth induced by squaric acid dibutyl ester, a therapy used for alopecia areata.
3 citations
,
October 2009 in “Iranian Journal of Basic Medical Sciences” This study suggests that the methanol extract of Buxus wallichiana has promising antioxidant properties and may promote hair growth, with varying effectiveness depending on the dosage and application form.
May 2025 in “International Journal of Trichology” In this case report, a 60-year-old man with rheumatoid arthritis and sudden hair whitening was treated with baricitinib, showing significant hair repigmentation and regrowth in 8 months, suggesting potential for baricitinib in managing canities subita, especially when linked to alopecia areata.
June 2026 in “International Journal of Innovative Science and Research Technology (IJISRT)” This study evaluated a natural, herbal-based powder formulation aimed at removing unwanted facial hair while promoting skin health, finding that the product was effective and well-suited for use based on physical properties and user feedback.
5 citations
,
October 2022 in “British Journal of Dermatology” This study reports that two phase III trials demonstrated the effectiveness of the oral Janus kinase inhibitor baricitinib at 2 mg or 4 mg daily for treating severe alopecia areata in adults, marking a potential advance in managing this condition.
May 2026 in “Quality in Sport” This study suggests that berberine may offer multiple benefits for women with polycystic ovary syndrome by improving metabolic and hormonal profiles, though further research is needed on its long-term effects on reproductive outcomes.
17 citations
,
April 2023 in “British Journal of Dermatology” This study suggests that off-label use of baricitinib in children under 12 with alopecia areata may improve hair regrowth, but further research is needed to confirm efficacy and safety.
July 2023 in “Clinical and Experimental Dermatology” In this study, combining baricitinib and prednisone effectively achieved complete hair regrowth in seven out of eight women with very severe alopecia areata, contrasting with less effective results from each drug used alone.
25 citations
,
October 2019 in “JAAD Case Reports” This article discusses the role of interleukin-15 and Janus kinase inhibitors in alopecia areata based on a murine model and reports no new experimental results.
September 2024 in “Journal of Ethnopharmacology” In this study, Terminalia bellirica extracts promoted hair regrowth in testosterone-induced AGA mice, possibly by inhibiting type II 5α-reductase activity and enhancing the MAPK signaling pathway.
This source reports that baricitinib significantly promotes hair regrowth in patients with severe alopecia areata, particularly those with a SALT score of 50 or higher, in clinical trials.
September 2016 in “International Journal of Herbal Medicine” This study undertook powder microscopy and preliminary phytochemical analysis of Buxus wallichiana's stem bark and leaves, identifying steroids, alkaloids, saponins, and glycosides without reporting clinical outcomes.
November 2023 in “JEADV Clinical Practice” In this study, adults with severe alopecia areata experienced greater improvements in hair regrowth, health-related quality of life, and reduced anxiety and depression symptoms after 36 weeks of treatment with baricitinib compared to placebo.
November 2016 in “Zoo biology” This study observed that increasing dietary vitamin C in capybaras significantly improved their skin, coat, and weight, though other nutrients might also have contributed to their improved condition.
2 citations
,
September 2025 in “Journal of Dermatological Treatment” In this study, baricitinib was effective in improving hair regrowth in patients with severe alopecia areata over one year, especially when treatment began within four years of symptom onset.