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    Glossary Apoptotic Keratinocytes

    skin cells self-destructing through programmed cell death

    Apoptotic keratinocytes are skin cells that are undergoing programmed cell death, a natural process where cells self-destruct when they are no longer needed or are damaged. This process helps maintain healthy skin by removing old or damaged cells, making way for new ones.

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    1. Geranyl Acetate Attenuates Para-phenylenediamine-induced Cytotoxicity, DNA Damage, Apoptosis, and Inflammation in HaCaT Keratinocytes Iranian journal of pharmaceutical research · 2025 · 1 citations
    2. Vitamin D inhibits captopril-induced cell detachment and apoptosis in keratinocytes 2010 · 8 citations
    3. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    4. Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism APOPTOSIS · 2011 · 52 citations
    5. 15-deoxy prostaglandin J2, the nonenzymatic metabolite of prostaglandin D2, induces apoptosis in keratinocytes of human hair follicles: a possible explanation for prostaglandin D2-mediated inhibition of hair growth Naunyn-Schmiedeberg's Archives of Pharmacology · 2016 · 11 citations
    6. Araliadiol Protects Human Keratinocytes From Oxidative Stress, DNA Damage, and Apoptosis via Activation of Antioxidant Signaling Frontiers in Bioscience-Landmark · 2026
    7. 5-Bromo-2′-deoxyuridine induced effluvium via p53-mediated CD326-positive keratinocyte apoptosis in C57BL/6 mice Journal of Dermatology · 2016
    8. Dihydrotestosterone Induces Keratinocyte Apoptosis by Activating ERK Signaling In Vivo · 2026
    9. Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P The FASEB Journal · 2001 · 125 citations
    10. Glycyrrhizic Acid Alleviates Osimertinib‐Induced Cutaneous Toxicity by Inhibiting Keratinocyte Apoptosis and Inflammation Phytotherapy Research · 2026
    11. Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways The Journal of Immunology · 2003 · 74 citations
    12. Abstract 1026: A non-apoptotic function for Mcl-1 as an activator of canonical Wnt signaling in keratinocytes Cancer Research · 2010
    13. Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes European Journal Of Oral Sciences · 2003 · 27 citations
    14. 0046 Antagonizing interferon-gamma receptor-1 signaling with topical SAMiRNA in human scalp skin protects hair follicles from immune privilege collapse and keratinocyte apoptosis Journal of Investigative Dermatology · 2026
    15. Continuous MEK inhibition by AZD6244 (ARRY-142886) results in exhaustion of the cutaneous keratinocytic stem cell pool and resembles senescence driven skin aging Journal of Clinical Oncology · 2008 · 2 citations
    16. Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis Archives of Toxicology · 2018 · 215 citations
    17. Effects of Microwave-Assisted Opuntia humifusa Extract in Inhibiting the Impacts of Particulate Matter on Human Keratinocyte Skin Cell Antioxidants · 2020 · 26 citations
    18. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes 2021 · 11 citations
    19. Clionasterol-Rich Fraction of Caulerpa racemosa against Particulate Matter-Induced Skin Damage via Inhibition of Oxidative Stress and Apoptosis-Related Signaling Pathway Antioxidants · 2022 · 5 citations
    20. Prevention of chemotherapy drug-mediated human hair follicle damage: combined use of cooling with antioxidant suppresses oxidative stress and prevents matrix keratinocyte cytotoxicity Frontiers in Pharmacology · 2025 · 4 citations
    21. 287 Mackerel fermented fish oil suppresses human keratinocyte damage caused by ultraviolet B radiation Journal of Investigative Dermatology · 2017
    22. Apoptosis and cutaneous biology Journal of The American Academy of Dermatology · 1997 · 60 citations
    23. Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia ˜The œAmerican journal of pathology · 2000 · 47 citations
    24. Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue Journal of Molecular Histology · 2015 · 6 citations
    25. Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation Oncology Letters · 2017 · 2 citations
    26. Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation Autophagy · 2023 · 2 citations
    27. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells Developmental dynamics · 1994 · 253 citations
    28. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations
    29. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006 · 128 citations
    30. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008 · 115 citations