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270-300 / 1000+ resultsresearch Keratoacanthoma and other types of squamous cell carcinoma with crateriform architecture: Classification and identification
This study seeks to clarify the terminology and classification of keratoacanthoma and similar squamous cell carcinoma lesions with central keratin-filled craters to aid in accurate differential diagnosis.
research A meta-analysis of the relationship between vitamin D receptor gene ApaI polymorphisms and polycystic ovary syndrome
This meta-analysis reported a significant association between vitamin D receptor gene ApaI polymorphism and polycystic ovary syndrome risk, with variations observed between Asian and Caucasian populations.
research 원저 : 안드로겐탈모증에 사용되는 보완대체의학에 관한 예비연구
This study observed that 70.2% of patients with androgenetic alopecia at a dermatologic clinic used complementary and alternative medicine, with topical applications being the most common form.
research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo
This study suggests that polyamines regulate CK2 enzyme activity and its subcellular distribution, as demonstrated in mouse models and cell cultures with elevated levels of ornithine decarboxylase.
research AIMP1 의 CD34+ 모낭 줄기세포의 증식 유도효과 연구
The study investigated the role of Aminoacyl-tRNA synthetase interacting multifunctional protein 1 (AIMP1) in hair follicle stem cell proliferation and its potential as a treatment for alopecia. AIMP1, when dissociated from the multi-tRNA synthetase complex, was found to be secreted by dermal papilla cells in a sonic hedgehog (Shh) signal-dependent manner. This secretion increased the proliferation of CD34+ hair follicle stem cells by promoting the wnt signaling pathway through inhibition of sFRP1, a known wnt antagonist. The research demonstrated that the N-terminal fragment of AIMP1 could be developed into a therapeutic peptide for hair loss. When applied topically to depilated mice, this peptide significantly accelerated hair growth, especially when formulated with carbomer. The findings highlighted a novel mechanism of AIMP1 action and its potential application in alopecia treatment.
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research 891 Comparison of phenotypes and transcriptomes of mouse skin-derived precursors and dermal mesenchymal stem cells
This study reported that mSKPs and DMSCs share similarities in biological characteristics but exhibit distinct transcriptome profiles, with mSKPs being more immune-related and DMSCs more associated with differentiation and disease pathways.
research Wool Keratin-Associated Protein Genes in Sheep—A Review
This review explains the genetic diversity of sheep wool keratin-associated protein genes and explores how this variation might be leveraged for selective breeding to enhance wool fiber traits.
research e-Poster : Autologous PRP and PPP: A potential therapeutic tool for promoting hair growth (초)
research K31 as a novel marker for clear secretory cells in human eccrine sweat glands
This research identified K31 as a new marker for distinguishing clear secretory cells in human eccrine sweat glands, aiding in differentiating between distinct cell types within these glands.
research 4‐MAPC, a 5α‐Reductase Inhibitor, Reduces Rat Ventral Prostate Weight, DNA, and Prostatein Concentrations
In this study, 4‐MAPC treatment reduced ventral prostate weight in rats primarily through decreased synthetic activity, with testosterone propionate increasing prostate weight and activity at pharmacologic doses.
research Meeting Abstracts
research A phase I study of MK-5108, an oral aurora A kinase inhibitor, in both monotherapy and in combination with docetaxel in patients with advanced solid tumors.
This study found that MK-5108 is well tolerated at high doses as monotherapy in cancer patients, showing stable disease and some antitumor activity, particularly in combination with docetaxel.
research Polymorphism of keratin-associated protein (KAP) 7 gene and its association with wool traits in Rambouillet sheep
This study suggests that the KAP 7 gene may serve as a potential molecular marker for genetic selection to improve staple length and greasy fleece weight in Rambouillet sheep.
research Automated Machine Learning Analysis of Patients With Chronic Skin Disease Using a Medical Smartphone App: Retrospective Study
This study reported that AutoML effectively modeled itching and pain development, as well as app use, in patients with chronic eczema or psoriasis using a smartphone monitoring app, revealing that factors like BMI, age, and disease activity significantly influenced app engagement.
research Field Cancerization: From Molecular Basis to Selective Field-Directed Management of Actinic Keratosis
This book reviews actinic keratosis from a multidisciplinary perspective, covering topics such as epidemiology, immunology, and clinical manifestations, but reports no new research results.
research Efficacy of Korean Red Ginseng in the Treatment of Alopecia Areata
In this study, Korean red ginseng combined with corticosteroid injections showed potential efficacy in treating alopecia areata over 12 weeks, suggesting it as a useful complementary treatment.
research GESTÃO DA QUALIDADE E O IMPACTO DE SUA APLICAÇÃO NOS SERVIÇOS PÚBLICOS
This collection of interdisciplinary studies highlights research from various institutions on topics relevant to Brazilian social development, but it reports no new empirical findings.
research Kevis P.F. – an adjunctive hair maintenance option
This article discusses the introduction and market presence of the Italian hair product Kevis but presents no new clinical findings.
research Alopecia Areata in Korea (1982–1994)
This study found that immunotherapy with DNCB or DPCP showed better therapeutic effects than intralesional triamcinolone acetonide for patients with bald areas greater than 50 cm², including alopecia totalis and universalis.
research Deletions in the KAP6-1 gene are associated with fiber traits in cashmere-producing goats
This study found that specific variants of the KAP6-1 gene in cashmere-producing goats were associated with changes in fiber diameter and length, suggesting potential as genetic markers for fiber improvement.
research Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy
This study found that keratin-associated proteins form part of the developing exocuticle and a-layer in hair fiber cuticle cells, while cornified envelope proteins were absent.
research Polymorphisms in Genes Involved in Steroidogenesis in the Development of Severe Acne
This study found that SNPs in the MVK, ARPC1B, and CA2 genes may indicate a genetic predisposition for severe acne related to steroidogenesis.
research Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial
In this study, researchers found that a polyphenolic extract from Annurca apples, high in procyanidin B2, increased hair growth, density, and keratin content in healthy subjects after 2 months of use, and stimulated keratin biosynthesis in vitro.
research CHARACTERISTICS AND ALOPECIA ACTIVITY OF PAKIS GAJAH (ANGIOPTERIS EVECTA (G.FORST) HOFFM.) GROWING IN GALUNGGUNG MOUNTAINSIDE, WEST JAVA
This study found that water fractions of Angiopteris evecta stimulated hair growth in male rabbits, suggesting potential alopecia treatment benefits pending further research in humans.
research Characterisation of Ovine KRTAP19-3 and Its Impact on Wool Traits in Chinese Tan Sheep
In this study, researchers identified six unique genetic variants of a sheep gene, KRTAP19-3, with specific variants linked to changes in wool fibre traits, such as increased fibre diameter variability, suggesting these genetic differences affect wool characteristics in Chinese Tan sheep.
research Evaluation of dermoscopy in differential diagnosis of facial actinic keratosis
This study concluded that a combination of three specific dermoscopy features provides the highest diagnostic value for distinguishing actinic keratosis from other facial lesions.
research Guidelines for the Management of Patients with Alopecia Areata in Korea: Part II Systemic Treatment
This study produced updated treatment guidelines for severe alopecia areata patients in Korea, highlighting the efficacy of systemic corticosteroids, oral cyclosporine, and Janus kinase inhibitors.
research Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands
This research reported that AKR1C enzyme expression, particularly AKR1C4, in scalp sebaceous glands decreases with age, suggesting potential age-related changes in androgen metabolism affecting hair follicle health. Additionally, sulforaphane treatment increased AKR1C expression in related cell types.