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    Glossary Antiandrogenic Activity

    inhibits effects of male sex hormones like testosterone

    Antiandrogenic activity refers to the ability of certain substances to inhibit the effects of androgens, which are male sex hormones like testosterone. This activity is important in treating conditions like androgenic alopecia (male-pattern baldness) and prostate cancer, as it helps reduce the influence of these hormones on hair follicles and prostate cells.

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    1. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 16 citations
    2. Antiandrogenic activity of Riboflavin 5′-phosphate (FMN) in 22Rv1 and LNCaP human prostate cancer cell lines European Journal of Pharmacology · 2022 · 1 citations
    3. Novel Synthetic Steroid Derivatives: Target Prediction and Biological Evaluation of Antiandrogenic Activity Current Issues in Molecular Biology · 2025
    4. Antiandrogenic activities of<i>Glycyrrhiza glabra</i>in male rats International Journal of Andrology · 2009 · 15 citations
    5. BIOLOGICAL ACTIVITY OF ANTIANDROGENS 1970 · 51 citations
    6. Anti-androgenic activities of Ganoderma lucidum Journal of Ethnopharmacology · 2005 · 70 citations
    7. Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum Food Chemistry · 2006 · 64 citations
    8. Anti-androgenic Activity of Myricae Cortex. Isolation of Active Constituents from Bark of Myrica rubra. Biological & Pharmaceutical Bulletin · 2001 · 51 citations
    9. Reversal of androgenetic alopecia by topical ketoconzole: Relevance of anti-androgenic activity Journal of Dermatological Science · 2006 · 38 citations
    10. Enzyme Inhibitory Activity of Certain Vegetables Indigenous in Iran as Potential Antiandrogens Journal of Food Biosciences and Technology · 2018
    11. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    12. Evaluation of 5α-reductase inhibitory activity of certain herbs useful as antiandrogens Andrologia · 2013 · 33 citations
    13. Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide Journal of Medicinal Chemistry · 2008 · 88 citations
    14. Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum) I. Active Constituents Inhibiting Testosterone 5.ALPHA.-Reductase. Biological & Pharmaceutical Bulletin · 2002 · 38 citations
    15. Multiple readout assay for hormonal (androgenic and antiandrogenic) and cytotoxic activity of plant and fungal extracts based on differential prostate cancer cell line behavior Journal of Ethnopharmacology · 2014 · 19 citations
    16. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005 · 20 citations
    17. Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities Plants · 2022 · 7 citations
    18. Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment F1000Research · 2021 · 8 citations
    19. Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment F1000Research · 2021 · 1 citations
    20. Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment F1000Research · 2021
    21. Connarus semidecandrus Jack Exerts Anti-Alopecia Effects by Targeting 5α-Reductase Activity and an Intrinsic Apoptotic Pathway Molecules · 2022 · 2 citations
    22. Synthesis, antiproliferative activity, acute toxicity and assessment of the antiandrogenic activities of new androstane derivatives Archives of Pharmacal Research · 2011 · 10 citations
    23. 5α-Reductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives International Journal of Biological Macromolecules · 2011 · 26 citations
    24. Referee report. For: Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment [version 3; peer review: 2 approved] Faculty of 1000 Research Ltd · 2021
    25. Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams European Journal of Medicinal Chemistry · 2010 · 23 citations
    26. Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3 Steroids · 2008 · 15 citations
    27. Comparison Between Two Different Hamster Models used for the Determination of Testosterone and Finasteride Activity Asian Journal of Animal and Veterinary Advances · 2010 · 12 citations
    28. 17-Oximino-5-androsten-3β-yl esters: synthesis, antiproliferative activity, acute toxicity, and effect on serum androgen level Medicinal Chemistry Research · 2010 · 7 citations
    29. Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity Journal of Investigative Dermatology · 1995 · 37 citations
    30. [Antiandrogen therapy of acne, falling hair and hirsutism (author's transl)]. PubMed · 1980