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Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

3α, 17β-androstanediol-glucuronide is not a useful marker for androgen excess but may help monitor certain treatments.

Testosterone and some of its forms can strongly stimulate oil gland growth in skin.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Women with hyperandrogenism have higher androgen levels and lower SHBG, which may contribute to conditions like excessive hair growth and early puberty.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Androgens significantly affect female hair loss, and hormonal treatments may help.

Testosterone therapy can help improve mood, sexual function, and bone health in women with low androgen levels, but more research is needed to establish safe and effective guidelines.

A yeast-based test can detect the steroid methyltestosterone in urine longer than traditional methods.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Birth control pills and cyproterone acetate can help treat acne in women, especially when linked to hormonal issues.

Skin problems in PCOS, like excess hair, acne, and hair loss, may not always indicate high male hormone levels and need careful diagnosis for proper treatment.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.