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      Virilizing Leydig Cell Tumor of the Ovary: From Presentation to Treatment - A Case Report

      research Virilizing Leydig cell tumor of the ovary: from presentation to treatment - a case report

      May 2025 in “International Journal of Reproduction Contraception Obstetrics and Gynecology”
      In this case report, the researchers described a postmenopausal woman with androgenic symptoms who was found to have a benign Leydig cell tumor of the left ovary, indicated by elevated testosterone levels and MRI findings, which was successfully treated with surgery.
      A Very Rare Reason for Hyperandrogenism: Adrenal Tumor Case

      research A Very Rare Reason for Hyperandrogenism: Adrenal Tumor Case

      March 2023 in “Bagcılar medical bulletin”
      This case report highlights a rare diagnosis of an androgen-secreting adrenal tumor in a patient with hyperandrogenism and virilization symptoms, emphasizing the role of gynecologists in early detection.
      Androgen- and Estrogen-Secreting Adrenal Cancers

      research Androgen- and Estrogen-Secreting Adrenal Cancers

      14 citations , December 2010 in “Seminars in Oncology”
      This review discusses the diagnostic challenges of androgen and estrogen-secreting adrenal tumors and highlights that the presence of metastases is the most reliable indicator of malignancy; it reports no new clinical findings.
      The Evaluation and Management of Hirsutism

      research The evaluation and management of hirsutism*1

      195 citations , May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”
      This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.
      Differential Diagnosis of Hyperandrogenism in Women with Polycystic Ovary Syndrome

      research Differential Diagnosis of Hyperandrogenism in Women with Polycystic Ovary Syndrome

      35 citations , March 2012 in “Experimental and Clinical Endocrinology & Diabetes”
      This article discusses various causes of hyperandrogenism in women and highlights diagnostic considerations for conditions such as PCOS, NCCAH, Cushing's disease, and androgen-secreting tumors, without reporting new clinical results.
      Androgenic Alopecia in Females: Diagnosis and Treatment

      research Androgenic Alopecia

      14 citations , July 1987 in “Dermatologic Clinics”
      This article reviews current evaluation and treatment options for androgenic alopecia in women and reports no new clinical results.
      Hirsutism in Adolescent Females

      research Hirsutism in the Adolescent Female

      13 citations , June 1989 in “Pediatric clinics of North America/˜The œPediatric clinics of North America”
      This article reviews assessment and management strategies for adolescent females with excessive hair growth and highlights the importance of evaluating potential androgen sources.

      research Endocrinology Update: Hirsutism.

      12 citations , December 2016 in “PubMed”
      This review discusses causes, diagnostic guidelines, and management strategies for hirsutism, highlighting the need for appropriate evaluations and treatment considerations in different patient populations, but reports no new clinical results.
      Hirsutism

      research Hirsutism

      12 citations , May 2005 in “Current obstetrics and gynaecology/Current obstetrics & gynaecology”
      This review discusses the causes and treatment strategies for hirsutism, emphasizing that combination therapy targeting androgen suppression and hair removal techniques is most effective; no new clinical results are reported.

      research Hirsutism in Women.

      11 citations , August 2019 in “PubMed”
      This review discusses the causes, evaluation, and treatment options for hirsutism in women, but reports no new clinical results.
      The Evaluation and Management of Hirsutism

      research The Evaluation and Management of Hirsutism

      11 citations , May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”
      This review explores the evaluation and treatment of hirsutism, emphasizing a systematic approach to uncovering its causes and recommending combination therapies for effective management, but presents no new results.
      The Evaluation and Treatment of Hirsute Women

      research The Evaluation and Treatment of Hirsute Women

      3 citations , November 2005 in “Women's health”
      This narrative review discusses various causes and treatments of hirsutism in women, emphasizing the importance of identifying androgen-secreting tumors, but does not present new study results.
      Hirsutism and Virilization in the Female

      research Hirsutism and Virilization in the Female

      2 citations , January 2013 in “Elsevier eBooks”
      This chapter reviews the causes and underlying steroid pathways of hirsutism and virilization in women, detailing relevant conditions and laboratory assays without reporting new clinical results.
      Diagnosing Polycystic Ovary Syndrome

      research Diagnosing polycystic ovary syndrome

      2 citations , May 2006 in “Women's Health Medicine”
      This article discusses polycystic ovary syndrome, describing its diagnostic criteria and noting that it is a common cause of anovulatory infertility and hirsutism, without reporting new research findings.

      research Hirsutism in Children: A Comprehensive Review of Etiology, Clinical Evaluation and Contemporary Management

      1 citations , December 2025 in “World Journal of Biology Pharmacy and Health Sciences”
      This review highlights that pediatric hirsutism, often linked to endocrine, metabolic, genetic, or neoplastic disorders, requires comprehensive evaluation to prevent long-term health issues, integrating advancements in androgen biosynthesis understanding and diagnostic and management strategies.
      Pathogenesis and Causes of Hirsutism

      research Pathogenesis and causes of hirsutism

      1 citations , January 2006
      This article reviews the pathophysiology and causes of androgen-mediated hair growth in hirsutism but does not report any clinical outcomes; treatment aspects are discussed separately.

      research Postmenopausal Occult Ovarian Disease With Hirsutism – A 6-Year Follow-up Course

      May 2026 in “Annals of Internal Medicine Clinical Cases”
      This case report describes a postmenopausal woman with androgenic alopecia and progressive hirsutism who, despite normal imaging, had significantly elevated testosterone due to a Leydig cell tumor, revealed after surgical exploration; the condition improved post-surgery, underscoring the importance of considering such tumors in similar presentations.

      research O-11 DIAGNOSTIC CHALLENGES IN POSTMENOPAUSAL HYPERANDROGENISM: REPORTS OF TWO CASES

      January 2026 in “JCEM Case Reports”
      This case study describes two postmenopausal women with severe androgen excess symptoms, diagnosed with ovarian hyperthecosis and stromal hyperplasia, emphasizing the challenges in differentiating these benign conditions from androgen-secreting tumors and the importance of surgical and histopathological evaluation for correct diagnosis and management.

      research Postmenopausal hyperandrogenism of ovarian origin

      October 2025 in “F1000Research”
      In this case series, the authors reported that postmenopausal hyperandrogenism should be carefully evaluated to diagnose potential androgen-secreting tumors, with Sertoli-Leydig cell tumors identified as a common cause.

      research Approach to the Patient: Hirsutism

      April 2025 in “The Journal of Clinical Endocrinology & Metabolism”
      This study highlights the global prevalence of hirsutism in women and reviews its diagnostic criteria, potential underlying causes like polycystic ovary syndrome, and treatment options, emphasizing the need for tailored, multifaceted management and acknowledging the distress it causes patients.

      research Ovarian Hyperthecosis Presenting as Polycythemia

      December 2024 in “AACE Clinical Case Reports”
      This study highlights a rare case of ovarian hyperthecosis in a 58-year-old postmenopausal woman, presenting with polycythemia and severe hyperandrogenism symptoms, with resolution of symptoms following laparoscopic bilateral oophorectomy.