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Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

Chromosomal differences affect how muscle cells respond to testosterone.

Effective PCOS treatments require targeting specific signaling pathways.

New testosterone analogs show promise for male contraception with better activity and potentially fewer side effects.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

A specific DNA sequence caused hair loss in male mice by activating immune cells and increasing a certain immune signal.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.

The document concluded that FDA-approved treatments like minoxidil and finasteride are effective for hair loss, while the effectiveness of natural remedies and other non-approved treatments is not well-supported by evidence.

The document concludes that accurate diagnosis and treatment are crucial in dermatology, and it presents various findings on skin conditions and treatments.

Genes controlling hair growth and immune response are disrupted in male pattern baldness.

Finasteride helps hair growth and prostate issues but may cause sexual side effects and increase tumor risk.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Colorectal cancer development involves both genetic changes and epigenetic alterations like DNA methylation and microRNA changes.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

Smoking harms skin health, causing slower wound healing, more wrinkles, and worsening some skin conditions, but may protect against certain others.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Hormone therapies like birth control pills and spironolactone are safe and effective for treating women's adult acne.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

Cognitive behavioral strategies help women with PCOS make lifestyle changes to improve their health.

Age, smoking, and lower BMI increase facial wrinkles; men wrinkle more than women, except in old age; pale skin and certain hormonal factors can protect against wrinkles.

Early diagnosis and treatment of PCOS is crucial to reduce emotional distress and health risks.

Vitamin D deficiency is common in women with PCOS and linked to some metabolic problems, but not the main cause of their metabolic issues.

The document concludes that more research is needed to fully understand the causes of PCOS.