97 citations
,
November 1986 in “Journal of Steroid Biochemistry” This review discusses the pharmacological properties and clinical applications of cyproterone acetate and similar antiandrogens, noting previous failures in local applications due to concentration limitations; it reports no new empirical results.
86 citations
,
July 2002 in “Clinical and Experimental Dermatology” This review discusses female pattern hair loss, emphasizing its complex causes and the limited treatment options available, and reports no new clinical results.
38 citations
,
December 2009 in “Therapeutic Advances in Medical Oncology” This discussion proposes a model to incorporate patients with hormone-resistant prostate cancer into the existing framework by redefining hormone resistance and exploring new therapeutic approaches.
12 citations
,
August 2000 in “Fertility and Sterility” Topical finasteride doesn't reduce DHT levels, hinting at an endocrine role in hair loss.
10 citations
,
November 1997 in “British Journal of Dermatology” This study found that the non-steroidal antiandrogen RU58841 increased hair growth rates and promoted hair cycle initiation in balding human scalp grafts on testosterone-conditioned nude mice, indicating a positive effect on hair growth.
9 citations
,
March 2001 in “Clinics in dermatology” This review examines the causes, assessment, and treatment options for hirsutism but presents no new clinical findings, highlighting the need for further research on managing this condition.
6 citations
,
August 1996 in “The Journal of Clinical Endocrinology and Metabolism” MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.
3 citations
,
October 2010 in “Wiley-VCH Verlag GmbH & Co. KGaA eBooks” Finasteride safely treats enlarged prostate and male-pattern baldness.
January 2023 in “Archives of Disease in Childhood Education & Practice” This article describes the causes of hirsutism, introduces a novel assessment tool, and suggests strategies for investigation and management, but provides no new experimental results.
January 2003 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This review discusses the dermatological impacts of hypogonadism in men, including skin thinning, reduced body hair, and skin reactions to testosterone therapy, but reports no new clinical results.
83 citations
,
October 2012 in “International Journal of Oncology” In this in vitro study, wedelolactone induced selective apoptosis in prostate cancer cells by inhibiting 5-Lox activity, suggesting it may have potential as a treatment for prostate cancer.
23 citations
,
February 2021 in “Journal of Endocrinological Investigation” This review discusses the impact of COVID-19 on the endocrine system and reports no clinical results; the authors emphasize the need to investigate endocrine damage during and after COVID-19 infection.
2 citations
,
July 2025 in “Journal of Ovarian Research” This study found that among women with PCOS, a bedtime after midnight was independently linked to higher androgen levels and decreased lean muscle mass.
19 citations
,
June 1999 in “Steroids” This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.
15 citations
,
April 2008 in “Steroids” This study found that pregnane derivatives with higher lipophilicity, like compound 9d, had stronger androgen receptor binding and greater antiandrogenic effects in rats, correlating relative binding affinity with log P values.
5 citations
,
June 2004 in “The Journal of The British Menopause Society” This study found that testosterone therapy can enhance sexual satisfaction and mood in surgically menopausal women on oestrogen, though ongoing monitoring and research are needed to assess long-term safety and effects in other groups.
2 citations
,
August 2025 in “Harm Reduction Journal” This study highlights the severe health risks and dependence associated with non-medical androgen use among gym-goers, stressing the need for specialized primary care and harm-reduction strategies due to potentially fatal outcomes even after prolonged cessation.
September 2017 in “Journal of Investigative Dermatology” In this study, the novel ASAXA-μCT imaging method identified that the shrinkage of sweat glands with aging causes dermal defects, reducing skin elasticity and contributing to wrinkling and sagging.
131 citations
,
September 2017 in “Molecular and Cellular Endocrinology” This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.
60 citations
,
May 2011 in “Endocrinology and Metabolism Clinics of North America” This article discusses the association between hypertension and polycystic ovary syndrome, highlighting the need for managing related risk factors, but reports no new clinical results.
23 citations
,
May 1984 in “Journal of the American Geriatrics Society” Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.
19 citations
,
January 2015 in “Indian Journal of Dermatology” In this study, researchers observed that 90% of patients with PCOS had cutaneous manifestations, with acne most common, and found associations between these skin conditions and high insulin or testosterone levels.
12 citations
,
May 1989 in “Postgraduate Medicine” This article discusses treatments for male pattern baldness, noting that minoxidil is effective for improving baldness at the scalp vertex in young men, and reports no new clinical results.
November 2025 in “Cureus” This review discusses the link between PCOS and acne, highlighting the roles of hyperandrogenism and insulin resistance, but it reports no new clinical findings.
10 citations
,
April 2018 in “Maturitas” This review discusses hormonal changes during menopause, emphasizing the relative androgen excess and the role of insulin resistance, and reports no new clinical findings.
37 citations
,
January 1997 in “Clinics in Dermatology” This study found that women with androgenetic alopecia and alopecia areata had significantly lower serum ferritin levels compared to women without hair loss.
23 citations
,
January 2021 in “Biomedicine & Pharmacotherapy” This study found that dihydrotestosterone induced hair loss and changes in hair morphology in male C57BL/6 mice, effects that could be partially reversed by the AR antagonist bicalutamide.
6 citations
,
September 1998 in “The Journal of The British Menopause Society” This review discusses the changes in androgen levels with age in women and the potential benefits of testosterone replacement therapy as part of hormone replacement therapy for postmenopausal women, but it reports no new clinical results.
May 2019 in “Gastroenterology” Androgen lowering medications don't significantly change HCV-related liver cancer risk in men.
24 citations
,
September 2001 in “Journal of The American Academy of Dermatology” Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.