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The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

The patient's high testosterone was reduced by a medication that suppresses gonadotropin.

Certain diets can affect skin conditions, but more research is needed to understand these relationships fully.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

Herbal compounds like ricinoleic acid, quercetin-3-O-rutinoside, and hinokiflavone may be safe and effective for treating hair loss.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Healthy lifestyle changes can significantly improve skin health as you age.

COVID-19 may harm male reproductive health and lower testosterone levels, potentially affecting fertility and causing erectile dysfunction. More research is needed.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

The combined treatment for hair loss is effective, easy to use, and has mild side effects.

The 2023 guideline for PCOS suggests using updated diagnostic criteria, assessing related health risks, and recommends lifestyle changes and specific treatments for symptoms and fertility issues.

The 2023 guideline advises a detailed approach for PCOS, focusing on early detection, lifestyle and medical treatments, and managing health risks.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Androgens cause oil-producing skin cells with androgen receptors to mature and produce more oil.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Genetic variants linked to ten skin diseases were found, showing both immune and non-immune factors play a role.

LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.

Cytochrome P-450 enzymes in the skin help break down various substances and could be targeted to treat skin conditions.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.