114 citations
,
December 1951 in “Archives of Dermatology” This article reviews the effectiveness of adrenal cortex compounds E and F in treating various connective tissue disorders and reports no new clinical findings.
88 citations
,
July 1958 in “Nature” This study reported the first known occurrence of citrulline in an animal protein, specifically in the fibrous protein of hair follicle inner root sheaths.
76 citations
,
December 2011 in “Journal of Cell Science” This study found that keratins have evolutionarily conserved and domain-selectively enriched amino acids, which likely reflect their unique structural roles, with distinct patterns observed among epidermal, hair, and simple-type epithelial keratins.
69 citations
,
January 2021 in “Journal of Biological Chemistry” This review discusses various amino acid-derived plant defensive compounds and highlights their potential as drug leads due to their potent antimicrobial properties, but reports no new experimental results.
65 citations
,
April 1999 in “Journal of Parasitology” This study found that all lesions in mice treated with a new topical formulation, WR 279,396, healed completely without relapse, outperforming other formulations and showing no toxicity.
44 citations
,
March 2016 in “Frontiers in cellular neuroscience” In this study using zebrafish, four bisbenzylisoquinoline derivatives were found to protect hair cells from aminoglycoside-induced damage without reducing antibiotic efficacy, potentially leading to therapies for patients undergoing such treatments.
41 citations
,
March 2017 in “PLoS neglected tropical diseases” This study found that isotretinoin, a drug commonly used for acne, inhibits polyamine transport in Trypanosoma cruzi, leading to trypanocidal effects, and suggests its potential as a treatment for Chagas disease without affecting mammalian cell viability.
39 citations
,
February 1990 in “The journal of cell biology/The Journal of cell biology” This study identified trichohyalin as an early differentiation marker in hair follicles, with potential structural roles related to alpha-helical formations, based on the partial characterization of its cDNA in sheep.
32 citations
,
December 1965 in “The Lancet” Argininosuccinic aciduria can cause hair loss.
29 citations
,
July 1996 in “Acta Paediatrica” This study found that an 11-month-old Japanese infant developed biotin deficiency while on a Japanese amino acid formula without biotin, which was resolved with biotin supplementation.
24 citations
,
April 2016 in “Experimental Dermatology” This study found that chemical treatments like perming, dyeing, and bleaching significantly alter amino acids and lipids in human hair, which may impact hair strength and quality.
23 citations
,
June 1950 in “American journal of diseases of children” This article discusses the interest in folic acid antagonists for leukemia treatment, noting their potential mechanism of interfering with cellular growth, but reports no new clinical results.
19 citations
,
June 2007 in “Veterinary Dermatology” In this study, amitraz was found to be an effective and well-tolerated treatment for resolving sarcoptic mange in alpacas, demonstrating no relapse over a 10-month follow-up.
18 citations
,
October 2022 in “JCI Insight” This study found that altered amino acid metabolism, specifically involving glutamic and aspartic acids, promotes neurovascular reactivity in rosacea, suggesting a potential metabolic target for treatment.
18 citations
,
October 2018 in “Nutrients” This study found that Annurca apple polyphenolic extracts reprogram hair follicle metabolism in mice, enhancing mitochondrial activity and keratin production while inhibiting some metabolic pathways.
17 citations
,
August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.
17 citations
,
August 1979 in “Journal of The American Academy of Dermatology” This study found that a histochemical stain using 4-dimethyl-aminocinnamaldehyde effectively distinguishes between plucked anagen and telogen hairs by causing the root ends of anagen hairs to develop a red color.
15 citations
,
January 2006 in “British Journal of Dermatology” This case study reports that the topical application of mometasone furoate ointment successfully reduced eruptions and promoted hair regrowth in a patient with amicrobial pustulosis.
13 citations
,
October 2008 in “PubMed” This study examined hair curvature in Japanese women, finding that 47% have curved hair, and identified structural differences in hair fiber, which resemble those in wool fibers.
12 citations
,
July 2017 in “International Journal of Cosmetic Science” This study found that N‐AOHPA was particularly effective as a silicone emulsifier for improving the condition of damaged hair by preventing amino acid dissolution from bleached hair.
11 citations
,
October 2024 in “Cell Death Discovery” In this study on mice with severe thermal skin burns, researchers found that administering 4-aminopyridine (4-AP) helped reduce inflammation and apoptosis, promoted angiogenesis, and accelerated wound healing by enhancing specific cellular behaviors and signaling pathways.
11 citations
,
December 2017 in “Orphanet Journal of Rare Diseases” This study found a previously unreported ST14 gene mutation in a patient with ichthyosis-hypotrichosis syndrome, highlighting novel skin and hair characteristics and emphasizing the critical role of the Asp482 amino acid in matriptase activation.
8 citations
,
October 2015 in “Asian Journal of Chemistry” A new method was created to accurately measure minoxidil and aminexil in hair loss treatments.
6 citations
,
January 2020 in “BMC Medical Genetics” In this study, researchers identified a novel STS gene (c.287G > A; p.W96*) mutation in Pakistani individuals with X-linked ichthyosis, expanding the understanding of its genetic causes and aiding in genetic counseling.
5 citations
,
January 2017 in “Elsevier eBooks” This review focuses on the roles of amino acids, peptides, and proteins in cosmetics, highlighting their importance in skin health and their potential for development in personal care products due to their unique properties and biocompatibility.
5 citations
,
October 2007 in “PubMed” This study discusses the effects of incorporating various amino acids in hair care products, noting improvements in hair surface properties and color retention when integrated with conditioners.
5 citations
,
May 1983 in “Australian journal of biological sciences” This study found that concurrent administration of cycloleucine with ethionine prevented the weakening of wool fibers in sheep, whereas reduced glutathione did not have the same effect.
4 citations
,
December 2018 in “Macedonian Journal of Chemistry and Chemical Engineering” This study developed a reliable RP-HPLC-DAD method, finding that amino acid concentrations in bleached hair decrease with higher hydrogen peroxide levels, notably affecting cystine.
4 citations
,
December 1989 in “The Journal of Dermatology” This study suggests that the amino acid composition of fibrous proteins in normal human hair is similar to that of stratum corneum proteins, particularly in cysteine and glycine content.
4 citations
,
January 1976 in “Archives of Dermatological Research” Metabolic disorders can cause hair structure defects and growth issues, but amino acid levels in hair remain normal.