9 citations
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January 2018 in “Journal of the European Academy of Dermatology and Venereology” A male patient developed frontal fibrosing alopecia after antiandrogen therapy for prostate cancer.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that conditional deletion of Mof in mice resulted in severe defects in skin development, including compromised epidermal differentiation and hair growth, leading to perinatal lethality.
January 2005 in “Pediatric Dermatology” This article presents a discussion on alopecia areata in infants and concludes that the condition's occurrence in this age group is not as rare as previously thought; it offers no new data.
10 citations
,
February 2019 in “Toxicological Sciences” This study reports that chemically induced short anogenital distance in male rat fetuses involved distinctive transcriptional changes, suggesting roles for estrogen and Wnt2 signaling in anogenital tissue development.
28 citations
,
October 2014 in “Development” This study revealed that frizzled 3 can fully rescue polarity defects in frizzled 6-null mice, while frizzled 6 can partially rescue defects in frizzled 3-null mice, highlighting conserved signaling roles in these proteins.
46 citations
,
December 1992 in “The Journal of Steroid Biochemistry and Molecular Biology” In this study, researchers observed that testicular 17β-hydroxysteroid dehydrogenase deficiency in an inbred Arab population in Israel leads to genital ambiguity at birth and progressive virilization after puberty.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that hemoglobin α is upregulated in epidermal keratinocytes after UV exposure and may function as an antioxidant, particularly for hair follicle stem cells.
32 citations
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July 2017 in “Oncotarget” This study found that intermittent treatment with FTI lonafarnib and sulforaphane may be a promising therapeutic approach for children with Hutchinson-Gilford progeria syndrome, as it improved the cellular phenotype.
23 citations
,
October 2008 in “Journal of medicinal chemistry” This study suggests that PF-0998425 is an effective androgen receptor antagonist for sebum control and androgenetic alopecia with rapid metabolism reducing the risk of systemic side effects.
March 2023 in “Oxford University Press eBooks” 20 citations
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July 2005 in “Experimental dermatology” This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.
5 citations
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September 2021 in “Journal of The American Academy of Dermatology” This study found a high prevalence of beard and eyebrow alopecia in male patients with frontal fibrosing alopecia, and suggests a potential link between hormonal imbalances and the condition.
1 citations
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April 2017 in “Journal of Investigative Dermatology” In this study, D-OCT imaging revealed distinct structural and vascular changes in patients with frontal fibrosing alopecia, highlighting the technique's potential for diagnosing and monitoring the condition's activity.
69 citations
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May 2002 in “Journal of Investigative Dermatology” This study suggests that congenital atrichia with papular lesions may be more common than previously thought and proposes diagnostic criteria including the observation of hypopigmented whitish streaks on the scalp.
135 citations
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December 2006 in “PLoS Medicine” This study suggests that intermediate-size hyaluronate fragments may enhance keratinocyte proliferation and improve skin thickness in atrophic conditions through a CD44-dependent mechanism.
November 2025 in “Journal of Investigative Dermatology” Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.
8 citations
,
October 2016 in “Actas Dermo-Sifiliográficas” This study found that men with frontal fibrosing alopecia exhibited more frequent facial papules, androgenetic alopecia, and body hair loss compared to women with the condition, and were generally older.
1 citations
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May 2022 in “International journal of molecular sciences” This study found that in Hutchinson–Gilford progeria syndrome, iPSCs committed to the keratinocyte lineage faster than normal cells, with LEF1 expression reduced and a partial rescue of the phenotype achieved through adenine base editing.
9 citations
,
October 2022 in “Journal of Molecular Neuroscience” This study reports a novel LSS gene mutation in an Egyptian family with alopecia intellectual disability syndrome 4, expanding the known clinical and genetic features of the condition.
2 citations
,
June 2013 in “Journal of Clinical Pathology” This article reviews the role of LMNA gene mutations, particularly in Hutchinson–Gilford progeria syndrome, but does not report new experimental findings.
24 citations
,
September 2015 in “JAAD case reports” This case report describes a patient with frontal fibrosing alopecia experiencing significant hair regrowth and reversal of cutaneous atrophy after treatment with the 5α-reductase inhibitor finasteride.
November 2025 in “Bioactive Materials” In this study, researchers developed a novel nucleic acid nanoparticle system incorporating quercetin, which they found enhances functional hair follicle regeneration and maintains epithelial structure stability in androgenetic alopecia by regulating hair follicle stem and dermal papilla cells.
2 citations
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November 2015 in “Journal of Investigative Dermatology Symposium Proceedings” This article discusses the creation of Alopecia Areata Uniform Protocols by the National Alopecia Areata Foundation to standardize clinical trials for alopecia areata treatments and reports no new results.
13 citations
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March 2020 in “Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy” This study used infrared spectroscopic imaging and scanning electron microscopy to reveal that alopecic hair has more irregular laminated structures and differing chemical profiles than normal hair, suggesting changes related to alopecia progression.
This article suggests that alopecia areata may be an early skin manifestation of hereditary hemochromatosis in individuals predisposed to autoimmunity, recommending iron status evaluation during AA diagnosis; it reports no new clinical results.
34 citations
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July 2020 in “American journal of human genetics” This study identified mutations in the SREBF1 gene that impair SREBP1 function, potentially contributing to IFAP syndrome by affecting skin, hair, and eye development.
6 citations
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January 2019 in “The American Journal of Dermatopathology” This study discovered that adipose tissue infiltration at the isthmus level appears significantly more often in frontal fibrosing alopecia cases compared to controls, suggesting a potential role in the condition's pathology.
1 citations
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January 2018 in “Acta dermato-venereologica” A teenager's hair with alternating white and dark bands, known as Pili annulati, is a genetic condition that is usually harmless and often considered attractive.
23 citations
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July 2003 in “Journal of Investigative Dermatology” Genetic testing for hairless gene mutations is crucial to correctly diagnose and treat atrichia with papular lesions.
September 2021 in “CRC Press eBooks” This review discusses fibrosing alopecia in a pattern distribution and highlights diagnostic features, but reports no new clinical results; the authors emphasize the value of trichoscopy and histology in diagnosis.