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Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.

Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.

The conclusion is that different types of hair loss in dogs and cats can be cosmetic or serious, and affected animals should not be bred.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Testosterone may slow down wound healing and increase inflammation.

Antiepileptic drugs can cause cosmetic side effects and affect menstrual cycles, fertility, and bone health in women with epilepsy.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The exact cause of growth hormone-responsive alopecia in dogs is unclear.

Testosterone therapy can modestly improve sexual function in menopausal women but should be used cautiously and is not recommended for routine measurement in sexual dysfunction or hirsutism.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Statins may be linked to reproductive organ conditions, and their risks should be monitored.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Hair mineral analysis might help diagnose diseases early, but standard methods are needed.

Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

Androgen therapy can help with symptoms like low libido in women, but more research is needed to understand its long-term safety and effects on health.

Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Hair analysis can help diagnose adrenal disorders non-invasively.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Ovarian steroid cell tumors should be considered in adults with hirsutism and high testosterone, with surgery as the main treatment.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

Postmenopausal hyperandrogenism, a condition with symptoms like increased hair growth and acne, is usually caused by PCOS but can also be due to other factors. It's diagnosed by checking testosterone levels and treated either by removing the adrenal tumor or through antiandrogen therapy.

The steroids allopregnanolone and allotetrahydrodeoxycorticosteron worsened absence seizures in rats.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.