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Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Human hair follicles produce and respond to erythropoietin, helping protect against stress.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Some women with acne have higher levels of free testosterone, which might suggest using hormonal treatments for acne.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

DHT, a testosterone byproduct, causes male pattern baldness.

Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.

Hidradenitis suppurativa improves with antiandrogen therapy.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Human skin produces sex hormones like estrogen and testosterone, influenced by ARO and StAR, which may affect skin elasticity and hair growth.

Women with early hair loss have higher blood pressure and aldosterone; screening and treatment may help.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.