January 2023 in “National journal of physiology, pharmacy and pharmacology” This study of South Indian patients with autoimmune rheumatic diseases using low-dose methotrexate reported that while mild adverse effects such as hair loss and nausea were common, serious events like cytopenia were less frequent, and folic acid supplementation significantly reduced their prevalence.
December 2024 in “Journal of Cancer Therapy and Research” In this study, researchers investigated the effects of Aqueous Artocarpus heterophyllus seed extract on testosterone enanthate-induced benign prostatic hyperplasia in adult Wistar rats, using three different dosages to assess its potential as an alternative therapy. Results are not reported in this abstract.
19 citations
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April 2011 in “Headache The Journal of Head and Face Pain” This study found that both topiramate and divalproex sodium were similarly effective in reducing headache frequency by over 50% among episodic migraine patients after three months of treatment.
294 citations
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February 1994 in “PubMed” This review highlights valproic acid's efficacy and tolerability as a first-line treatment for various seizure types in both adults and children, emphasizing its minimal neurological adverse effects compared to other antiepileptic drugs.
2 citations
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June 1985 in “PubMed” This study observed that ethylenthiourea's lethality increases with dose accumulation and ethanol co-administration, while impaired liver function and various adverse effects were noted in long-term treated rats.
June 2017 in “Journal of The American Academy of Dermatology” Tapinarof cream at 1% concentration is effective and better tolerated for treating atopic dermatitis than the 2% concentration.
66 citations
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July 2005 in “Journal of pediatric gastroenterology and nutrition” This case report describes acute liver injury in a 5-year-old Caucasian girl after ingesting the Chinese herbal product Shou-Wu-Pian, suggesting a potential link between this unregulated herbal remedy and hepatotoxicity.
37 citations
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January 2010 in “Internal Medicine” This case report highlights a 53-year-old woman who developed acute hepatitis after taking shou-wu-pian for eight months, suggesting that Chinese herbal preparations can sometimes cause liver damage.
September 2022 in “Research Square (Research Square)” This study found that caffeic acid treatment mitigated the negative effects of acrylamide toxicity in Wistar rats by normalizing tissue and serological indices.
This study found that holding abatacept infusions for four weeks or longer before elective hip or knee arthroplasty did not reduce the risk of post-operative infections or readmissions.
June 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found a specific T cell receptor that may be key in carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis, suggesting potential therapeutic targets.
6 citations
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December 2022 in “Anais Brasileiros de Dermatologia” 1 citations
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October 2011 in “Hospital Pharmacy” This article highlights the importance of recognizing, preventing, and reporting adverse drug reactions to the FDA's MedWatch program, but does not present new research findings.
This study found that tenuazonic acid from Alternaria alternata can cause significant damage to vital organs in mice at low doses and highlights the need for regulatory measures to manage its risk in agricultural products.
1 citations
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May 2001 in “Pharmacology & Toxicology” This review discusses the preclinical findings on cyproterone acetate and suggests that while it has a low potential cancer risk for patients, its tumor effects in female rats may involve both genotoxic and mitogenic mechanisms.
5 citations
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January 2010 in “Medicinal Plants - International Journal of Phytomedicines and Related Industries” This review discusses the diverse pharmacological activities of T. procumbens, such as hypotensive and hair growth-promoting effects, but reports no new clinical findings.
15 citations
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July 2022 in “Frontiers in Pharmacology” This study suggests that Cepharanthine, a monomer in traditional Chinese medicine, may help treat COVID-19 by affecting multiple signaling pathways, and that TNF and IL-17 inhibitors used in rheumatoid arthritis, ankylosing spondylitis, and gouty arthritis might also be beneficial.
This study reports on a new semantic annotation approach used to identify substances in MEDLINE abstracts responsible for adverse drug reactions, with promising performance shown by a prototype system.
September 2016 in “한국임상약학회지” In this study, ibuprofen, menthol, and cetirizine were found to potentially prevent or slow down damage to human dermal fibroblast cells caused by intermittent fever in early alopecia.
July 2003 in “Pediatrics in review” This article reviews 12 newly approved drugs with pediatric indications from 2001, discussing their clinical importance for general pediatricians, but reports no new clinical results.
4 citations
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March 2002 in “International journal of toxicology” In this study on tolerant rats, maternal and developmental toxicity from levo-alpha-acetyhnethadol hydrochloride were observed at all doses, without specific fetal toxicity or teratogenic effects.
January 2011 in “Arqueología, historia y viajes sobre el mundo medieval/Arqueología, historia y viajes sobre el mundo medieval” In this study, acute liver disease occurred in five patients, including four children, after treatment with sodium valproate, leading to the death of three patients.
May 2019 in “Asian Journal of Pharmaceutical and Clinical Research” This study found that the ethyl acetate and chloroform fractions of Eclipta prostrata Linn. exhibited significant anti-inflammatory activity in a carrageenan-induced paw edema model and showed notable anti-arthritic potential in a formaldehyde-induced arthritis model.
June 2017 in “Poster presentations” In this study, the safety profiles of four treatments for early rheumatoid arthritis were assessed over one year, and the most serious side effects necessitating treatment discontinuation were noted in the leflunomide group, whereas no such withdrawals occurred in the methotrexate plus prednisolone group.
2 citations
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November 2025 in “Pharmacology Research & Perspectives” This study analyzed post-marketing data from the U.S. FDA Adverse Event Reporting System and identified both known and new safety concerns for Avacopan, an anti-neutrophil cytoplasmic antibodies-associated vasculitis treatment, emphasizing the need for monitoring during early treatment stages.
April 2020 in “Estudo & Debate” This study concluded that the pharmacy in Venâncio Aires complies with Good Manufacturing Practices, as significant microbial growth was only found in Paracetamol samples, while other materials showed no or insignificant growth.
1 citations
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October 2022 in “The American Journal of Gastroenterology” This case study describes a 29-year-old woman whose severe liver injury was primarily attributed to chronic arsenic exposure, highlighting the importance of recognizing metal toxicity in patient care.
22 citations
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November 2002 in “Clinical journal of oncology nursing” This article discusses arsenic trioxide as a treatment for refractory or relapsed acute promyelocytic leukemia, noting its effectiveness and manageable side effects.
This chapter reviews various types of aromatic compounds and provides references, but reports no new experimental results.
6 citations
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May 2023 in “Molecules” In this study, dry powder inhalers containing Cepharanthine were administered to rats with acute lung injury, significantly reducing pulmonary edema, hemorrhage, and inflammatory markers, suggesting its potential as an effective anti-inflammatory treatment when inhaled directly into the lungs.