Experimental Induction of Tenuazonic Acid Toxicity in Mice Model

The study assessed the health risks of tenuazonic acid (TeA) from Alternaria alternata in tomatoes using a murine model. TeA was administered to mice both intra-peritoneally and orally, leading to significant health effects. Behavioral changes included decreased feed consumption and weight changes, with hair loss observed in both groups. Anatomical changes included spleen and liver enlargement and lesions. Haematological analysis showed neutrophilia in the IP group and neutropenia in the oral group. Biochemical analyses indicated oxidative stress, with elevated malondialdehyde and abnormal enzyme levels. Histological changes included non-alcoholic fatty liver and WBC infiltration. The study concluded that even small concentrations of TeA could severely damage vital organs, highlighting the need for regulatory measures to control TeA levels in food products.