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    Glossary Abiraterone

    inhibits androgen production to treat prostate cancer

    Abiraterone, also known as Zytiga, is a medication used primarily to treat prostate cancer. It works by inhibiting an enzyme called CYP17, which is involved in the production of androgens (male hormones) that can fuel the growth of prostate cancer cells. By reducing androgen levels, abiraterone helps to slow the progression of the disease.

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    Research 30 of 82

    1. Abiraterone and spironolactone in prostate cancer: a combination to avoid Acta Clinica Belgica · 2018 · 9 citations
    2. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    3. Revising the role of the androgen receptor in breast cancer Journal of Molecular Endocrinology · 2014 · 68 citations
    4. Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 51 citations
    5. Are sex discordant outcomes in COVID-19 related to sex hormones? Seminars in Oncology · 2020 · 42 citations
    6. Redefining hormone resistance in prostate cancer Therapeutic Advances in Medical Oncology · 2009 · 38 citations
    7. HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond Endocrinology · 2019 · 30 citations
    8. Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation Psychoneuroendocrinology · 2013 · 19 citations
    9. Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 <i>in vitro</i> infection using a phenotypic screening strategy and network-analysis to predict their potential to treat covid-19 bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 13 citations
    10. Editorial: Androgen-dependent diseases and their treatment Frontiers in Endocrinology · 2024
    11. Management of Advanced Prostate Cancer Undergoing Major Shift Oncology times · 2011
    12. New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & therapeutics Frontiers in Oncology · 2023
    13. Hormone Blocking Anticancer Drugs 2015
    14. Reporting on Adverse Clinical Events Clin-Alert · 2021
    15. Alopecia With Endocrine Therapies in Patients With Cancer Oncologist · 2013 · 48 citations
    16. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011 · 218 citations
    17. Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies European Journal of Clinical Pharmacology · 2020 · 77 citations
    18. Androgenic Effects on Ventricular Repolarization Circulation · 2019 · 64 citations
    19. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020 · 40 citations
    20. Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress Schizophrenia Research · 2015 · 24 citations
    21. Androgen receptor: A promising therapeutic target in breast cancer Critical Reviews in Clinical Laboratory Sciences · 2019 · 21 citations
    22. Clinical characterization of men with long QT syndrome and torsades de pointes associated with hypogonadism: A review and pharmacovigilance study Archives of Cardiovascular Diseases · 2019 · 17 citations
    23. Recent discoveries and developments of androgen receptor based therapy for prostate cancer MedChemComm · 2015 · 17 citations
    24. A Review on Steroidal 5&#945;-Reductase Inhibitors for Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2011 · 17 citations
    25. Targets to treat androgen excess in polycystic ovary syndrome Expert Opinion on Therapeutic Targets · 2015 · 14 citations
    26. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    27. Repurposing steroidogenesis inhibitors for the therapy of neuropsychiatric disorders: Promises and caveats Neuropharmacology · 2018 · 10 citations
    28. COVID‐19, androgens, and androgenic alopecia Dermatological reviews · 2020 · 6 citations
    29. A randomized phase II trial on the addition of dutasteride to combined androgen blockade therapy versus combined androgen blockade therapy alone in patients with advanced or metastatic salivary duct carcinoma – the DUCT study protocol BMC Cancer · 2024 · 4 citations
    30. Androgen Receptor Ligands: Agonists and Antagonists Elsevier eBooks · 2017 · 2 citations