research 3,3-Diphenylpentane Skeleton as a Steroid Skeleton Substitute: Novel Inhibitors of Human 5α-Reductase 1
A new compound effectively inhibits human 5α-reductase 1.
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research A Woman With Iatrogenic Androgenetic Alopecia Responding To Finasteride
EF and PXE not closely related.
research Pilomatricoma Arising at a BCG Vaccination Site
A benign tumor developed at a girl's BCG vaccination site, not previously linked to the vaccine.
research Generalized Calcinosis Cutis Associated with Probable Leptospirosis in a Dog
A dog's skin calcification condition resolved without treatment after a bacterial infection.
research Severe Monilethrix Associated with Intractable Scalp Pruritus, Posterior Subcapsular Cataract, Brachiocephaly, and Distinct Facial Features: A New Variant of Monilethrix Syndrome?
A new severe form of monilethrix syndrome includes hair loss, scalp itching, cataracts, and distinct facial features.
research Clinical Case Notes: Lipoid Proteinosis - A Rare Disorder with Pathognomonic Lid Lesions
A baby boy with 13q deletion syndrome had eye cancer, a woman's vision improved after stopping a breast cancer drug, a man developed cataracts from using Propecia, and a rare skin disorder called Lipoid Proteinosis was discussed. Also, a tool called OCT is useful for diagnosing macular diseases.
research A Case of Satoyoshi Syndrome: A Multisystem Disorder
Steroid treatment greatly improved the symptoms of a boy with a rare disorder called Satoyoshi syndrome.
research A Simple In Vivo System for Studying Epithelialization, Hair Follicle Formation, and Invasion Using Primary Epidermal Cells from Wild-Type and Transgenic Ornithine Decarboxylase-Overexpressing Mouse Skin
The study introduced a tracheal xenotransplantation assay to investigate epithelialization, hair follicle formation, and tumorigenesis using primary epidermal cells from both wild-type and transgenic mice. It demonstrated that keratinocytes overexpressing ornithine decarboxylase (ODC) combined with v-Ha-ras infection became invasive and malignant, whereas those expressing only one of these factors did not. The assay was also effective for hair follicle reconstitution, with fresh keratinocytes and fibroblasts forming hair follicles more successfully than cultured cells. This system provided a controlled environment to explore keratinocyte physiology, gene expression, and hair follicle development, particularly when cell numbers were limited.
research Pseudopili Annulati in a Dark-Haired Individual: A Light and Electron Microscopic Study
A dark-haired Chinese girl had hair that looked banded under certain light but was normal under a microscope.
research Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia
Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
research Paradoxical Skin Reaction to Certolizumab: Overlap of Pyoderma Gangrenosum and Psoriasis in a Young Woman Treated for Ankylosing Spondylitis - Case Report with Literature Review
A young woman had a rare skin reaction to a medication for her joint disease, and a combination therapy improved her condition.
research Clinical Management of Cutaneous Adverse Events in Patients on Chemotherapy: A National Consensus Statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology
Proper skin toxicity management in chemotherapy is key to continuing treatment and keeping patient quality of life high.
research A Small Dose of Botulinum Toxin A Is Effective for Treating Androgenetic Alopecia in Chinese Patients
Small Botox dose effectively treats hair loss in Chinese men.
research A Critical Review on Obstetric Follow-Up of Women Affected by Systemic Lupus Erythematosus
Women with Systemic Lupus Erythematosus should have closely monitored pregnancies and avoid certain medications to improve their pregnancy outcomes.
research An Ovarian Leydig Cell Tumor Undetected by Ultrasound in a Postmenopausal Woman with Hirsutism and Hyperandrogenism
A postmenopausal woman's hirsutism and high testosterone levels improved after surgery for an ovarian tumor not seen on ultrasound.
research A Simple Method Using Ex Vivo Culture of Hair Follicle Tissue to Investigate Intrinsic Circadian Characteristics in Humans
Researchers developed a way to study human body clocks using hair tissue, which works similarly in both healthy and dementia patients.
research Two Familial Cases of Olmsted-Like Syndrome with a G573V Mutation of the TRPV3 Gene
A new genetic mutation in the TRPV3 gene causes Olmsted-like syndrome in a Mongolian family.
research A Human Vitamin D Receptor Mutation Causes Rickets and Impaired Th1/Th17 Responses
A vitamin D receptor mutation causes rickets and affects immune responses.
research A Comprehensive Approach to Hair Pathology of Horizontal Sections
A new method using visual aids to diagnose hair diseases was effective after brief training.
research A Rare Case of Woolly Hair with Unusual Associations
The document reports a unique case of woolly hair with a combination of conditions not previously seen together.
research Prevalent Founder Mutation c.736T>A of LIPH in Autosomal Recessive Woolly Hair of Japanese Leads to Variable Severity of Hypotrichosis in Adulthood
A specific gene mutation in Japanese people can cause varying degrees of hair thinning in adulthood.
research Worth a Second Look: A 72-Year-Old Man with Significant Fatigue and Weight Loss
A 72-year-old man had severe fatigue, weight loss, and frequent loose stools.
research Clinical, Histological, and Immunophenotypic Findings in a Mare with Mammary Lymphoma Associated with Anemia and Pruritus
A mare had severe symptoms and died from a large lymphoma.
research New Onset Alopecia and Hirsutism in a Postmenopausal Woman
A postmenopausal woman's hair loss and excess hair growth improved after surgery for ovarian hyperthecosis.
research Itraconazole in the Treatment of Acute and Recurrent Vulvovaginal Candidosis: Comparison of a 1-Day and a 3-Day Regimen
A 1-day or 3-day itraconazole treatment is effective for acute vulvovaginal candidosis, but recurrent cases may need longer treatment.
research Scd1 ab-Xyk: A New Asebic Allele Characterized by a CCC Trinucleotide Insertion in Exon 5 of the Stearoyl-CoA Desaturase 1 Gene in Mouse
A new mouse mutation causes skin and hair defects due to a gene change.
research Lupus Erythematosus-Like Lesions in a Carrier of X-Linked Chronic Granulomatous Disease: A Case Report and Personal Considerations
A woman with X-linked chronic granulomatous disease developed lupus-like skin lesions, improved with treatment, suggesting a unique skin condition in carriers.
research A Study on the Effect of the Leaf Essential Oil of Ocimum Gratissimum Linn. on Cyclophosphamide-Induced Hair Loss
Ocimum oil may promote hair growth and reduce hair loss from cyclophosphamide.
research Pilot Study of a Novel Treatment for Androgenetic Alopecia Using Enriched Cell Culture Medium: Clinical Trials
A new treatment for hair loss was tested and most participants saw their hair loss stop within 2-8 weeks, with up to 50% more hair after 4 months, and no side effects.
research A Risk-Benefit Assessment of Treatment with Finasteride in Benign Prostatic Hyperplasia
Finasteride helps reduce prostate size and symptoms in BPH but is less effective than terazosin and works best for larger prostates.