Itraconazole in the Treatment of Acute and Recurrent Vulvovaginal Candidosis: Comparison of a 1-Day and a 3-Day Regimen

April 2005 in “ Mycoses ”

Jiří Špaček, Vladimı́r Buchta

itraconazole triazole antifungal vulvovaginal candidosis alopecia areata azole therapy

Studysummary This study found that 1-day itraconazole therapy was more effective for acute vulvovaginal candidosis than for recurrent cases, where relapses occurred despite no yeast resistance. Our plain-language summary of this paper — not a Tressless recommendation.

Itraconazole, a systemic triazole antifungal, was evaluated for treating vulvovaginal candidosis in 60 patients, with 34 having acute and 26 having recurrent infections. Patients received either a 1-day regimen (twice 200 mg in 1 day) or a 3-day regimen (200 mg daily for 3 days). Cure rates 1 month post-treatment were 97.1% for acute cases and 76.9% for recurrent cases, with relapses in the latter group not due to yeast resistance. Side effects were minimal, except for one case of alopecia areata. Long-term and suppressive azole therapy was recommended for recurrent cases.

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