Treatment of Lymphocutaneous and Visceral Sporotrichosis with Fluconazole
TLDR Fluconazole is somewhat effective for skin-related sporotrichosis but less so for severe forms, and should be a backup treatment.
The study evaluated the effectiveness of fluconazole in treating 30 patients with sporotrichosis, a fungal infection. Patients received daily doses ranging from 200 to 800 mg. Among the 14 patients with lymphocutaneous sporotrichosis, 71% were cured. However, only 31% of the 16 patients with osteoarticular or visceral sporotrichosis responded to the treatment, with no documented cures. The study noted minimal toxic effects, except for alopecia in five patients. The findings suggested that fluconazole was only modestly effective and should be considered a second-line treatment for patients unable to take itraconazole.
