Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort

November 2018 in “ Antimicrobial agents and chemotherapy (Print) ”

George R. Thompson, Charles R. Krois, Verena K. Affolter, Angela Everett, Eeva Varjonen, Victoria R. Sharon, Anil Singapuri, Michael Dennis, Ian Howard Mchardy, Hong Sik Yoo, Dawn M. Fedor, Nathan P. Wiederhold, Phylicia Aaron, Angela C Gelli, Joseph L. Napoli, Stephen D. White

fluconazole alopecia telogen effluvium retinoic acid triazole retinoid responsive gene expression

Studysummary This study found that fluconazole was associated with telogen effluvium in both a rat model and human patients, although retinoic acid levels were not identified as a causal factor.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on aac.asm.org →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Hair Pull Test: Evidence-Based Update and Revision of Guidelines

36 citations , December 2016 in “Journal of The American Academy of Dermatology”

In this study, researchers evaluated the hair pull test and found that normal values should be reduced to two hairs or fewer, with no significant impact from hair washing, brushing, or lifestyle factors such as hair texture and medication use.

research Endogenous Retinoids in the Hair Follicle and Sebaceous Gland

50 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

This review examines the role of retinoic acid synthesis in hair follicles and sebaceous glands, focusing on its localization and function during normal and disease states, but reports no new results.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations , June 2005 in “Journal of Investigative Dermatology”

This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.

research Alopecia Associated with Fluconazole Therapy

2 citations , July 1996 in “Annals of Internal Medicine”

This letter argues that the association between fluconazole therapy and alopecia may be misattributed, suggesting instead that systemic fungal infections themselves could lead to hair loss.

research Alopecia Associated with Fluconazole Therapy

4 citations , July 1996 in “Annals of Internal Medicine”

This article discusses a report on reversible alopecia associated with fluconazole therapy and mentions other possible causes of hair loss but presents no new findings.

research Alopecia Associated with Fluconazole Therapy

63 citations , September 1995 in “Annals of internal medicine”

This study found that higher-dose fluconazole (400 mg/d) for two months or longer commonly causes reversible alopecia, which can be resolved by discontinuing or reducing the dosage.

research Binding of Steroid Hormones by the 105,000 x g Supernatant Fraction from Homogenates of Rat Skin and Variations During the Hair Cycle

35 citations , September 1972 in “Journal of Biological Chemistry”

This study observed that the binding of certain hormones in rat skin varies cyclically with the hair cycle phases, with testosterone showing maximum binding in the catagen phase.