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    Glossary Arginine

    amino acid involved in protein synthesis and nitric oxide production

    Arginine, also known as L-Arginine, is an amino acid that plays a crucial role in various bodily functions, including protein synthesis, wound healing, and the production of nitric oxide, which helps relax blood vessels and improve circulation. It is considered semi-essential, meaning the body can produce it, but supplementation may be necessary during periods of illness or stress.

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    1. THE LOCALIZATION AND SIGNIFICANCE OF ARGININE AND CITRULLINE IN PROTEINS OF THE HAIR FOLLICLE Journal of Histochemistry & Cytochemistry · 1963 · 46 citations
    2. The Enzymic Derivation of Citrulline Residues from Arginine Residues In Situ during the Biosynthesis of Hair Proteins that are Cross-Linked by Isopeptide Bonds Advances in experimental medicine and biology · 1977 · 45 citations
    3. Trichorrhexis Nodosa Secondary to Argininosuccinicaciduria Pediatric dermatology · 2007 · 33 citations
    4. AMINOGENIC ALOPECIA LOSS OF HAIR ASSOCIATED WITH ARGININOSUCCINIC ACIDURIA The Lancet · 1965 · 32 citations
    5. Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia Artificial Cells Nanomedicine and Biotechnology · 2016 · 17 citations
    6. Dietary management reverses grooving and abnormal polarization of hair shafts in argininosuccinase deficiency American Journal of Medical Genetics · 1991 · 15 citations
    7. Arginosuccinicaciduria American journal of diseases of children · 1974 · 10 citations
    8. Arginine Transferase Activity In Homogenates From Guinea-Pig Hair Follicles Journal of Investigative Dermatology · 1976 · 8 citations
    9. Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers Amino acids · 2021 · 7 citations
    10. The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects Journal of Cosmetic and Laser Therapy · 2013 · 5 citations
    11. A prospective real-world study evaluating serum levels of arginine and cysteine in women with chronic telogen effluvium: do we really need blanket prescription of amino acid supplementation? Clinical and Experimental Dermatology · 2022 · 1 citations
    12. Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model Biological Trace Element Research · 2022 · 1 citations
    13. The Effect of a Combination of an Arginine Silicate Complex and Magnesium Biotinate on Hair and Nail Growth in Rats (P06-026-19) Current developments in nutrition · 2019 · 1 citations
    14. Arginine Metabolic Disruption Impairs Hair Regeneration via ROS-Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia. PubMed · 2025
    15. Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia 2023
    16. Clinical study on the efficacy and tolerability of an oral supplement based on arginine, l-cystine, zinc and B6 vitamin (Cystiphane®) in patients with telogen effluvium Italian journal of dermatology and venereology · 2023
    17. Comment on 'A prospective real world study evaluating serum levels of arginine and cysteine in females with chronic telogen effluvium: do we really need blanket prescription with amino acid supplementation?' Clinical and Experimental Dermatology · 2022
    18. Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a µHair Follicle 3D Model Cosmetics · 2018
    19. The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine Biomaterials · 2014 · 36 citations
    20. EFFECTS OF α-MELANOCYTE-STIMULATING HORMONE AND [8-ARGININE]-VASOTOCIN UPON MELANOGENESIS IN HAIR FOLLICLE MELANOCYTES IN VITRO Journal of Endocrinology · 1981 · 12 citations
    21. A Sensitive Assay for the Enzyme Activity in Hair Follicles and Epidermis that Catalyses the Peptidyl-Arginine-Citrulline Post-translational Modification Current problems in dermatology · 2015 · 3 citations
    22. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2025
    23. Nitrogen‐Boosted H <sub>2</sub> O <sub>2</sub> Production of Arginine‐Polyphenol Nanozyme Drives Oxidative Eustress for Hair Regeneration Advanced Science · 2025
    24. Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia. PubMed · 2025
    25. 0749 Serine and arginine-rich splicing factor 3 regulates epidermal differentiation in cutaneous squamous cell carcinoma Journal of Investigative Dermatology · 2025
    26. 481 Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia Journal of Investigative Dermatology · 2024
    27. Transdermal L-Arginine and Hyaluronic Acid Delivery to Treat Androgenetic Alopecia through Dual Hormone Modulation and Anti-Inflammatory Action SSRN Electronic Journal · 2026
    28. Can hair be protected from oxidative damage during and after bleaching University of the Arts London Research Online (University of the Arts London) · 2018
    29. iε-(γ<sup>-Glutamyl</sup>) lysine cross-linkage in citrulline-containing protein fractions from hair Biochemistry · 1971 · 125 citations
    30. Trichohyalin, an intermediate filament-associated protein of the hair follicle. 1986 · 116 citations