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This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

Cocaine impairs male sexual behavior and alters testosterone metabolism in the brain.

Sebocytes play a key role in controlling androgen levels in human skin.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

Dutasteride makes alcohol less sedating and may lead to less drinking in men.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Neurosteroids show promise for treating epilepsy and more research is needed.

Androgens significantly affect female hair loss, and hormonal treatments may help.

Alternative treatments show promise for hair growth beyond traditional methods.

Finasteride doesn't affect sleep spindles in men.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Androgens can both increase and decrease hair growth in different parts of the body.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

DHT, a testosterone byproduct, causes male pattern baldness.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

The conclusion is that oral contraceptives and antiandrogens can treat hirsutism and acne in women with cutaneous hyperandrogenism, but more research is needed for effective treatments, especially for hair loss.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.