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Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

research Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

10 citations, August 1998 in “Journal of Investigative Dermatology”

The compounds tested could potentially treat hair loss and alopecia.

research Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men

7 citations, August 1996 in “The Journal of Clinical Endocrinology and Metabolism”

research Comparing the Frequency of Isotretinoin-Induced Hair Loss at <0.5 mg/kg/d Versus ≥0.5 mg/kg/d Dosing in Acne Patients: A Systematic Review

6 citations, February 2022 in “JAAD International”

Higher doses of isotretinoin may lead to more hair loss.

research Clinical Dose Ranging Studies with Finasteride, a Type 2 5α-Reductase Inhibitor, in Men with Male Pattern Hair Loss

5 citations, October 1999 in “Journal of The American Academy of Dermatology”

research Minoxidil Dose Response Study in Female Pattern Hair Loss Patients Determined to Be Non-Responders to 5% Topical Minoxidil

4 citations, January 2017 in “PubMed”

Increasing the dosage of minoxidil can help hair regrowth in women who didn't respond to the standard treatment.

research Natural Course of Epidermolysis Bullosa Simplex with Mottled Pigmentation in a Japanese Family with the p.P25L Mutation in KRT5

3 citations, January 2019 in “Journal of Dermatology”

The p.P25L mutation in the KRT5 gene causes a rare skin condition that worsens over time and may lead to hair loss starting in young adulthood.

research Minoxidil Dose Response Study in Female Pattern Hair Loss Patients Determined to Be Non-Responders to 5% Topical Minoxidil

1 citations, April 2017 in “Journal of Investigative Dermatology”

Higher minoxidil dose helps hair growth in non-responders without side effects.

research Updates from the British Association of Dermatologists 91st Annual Meeting, 5-7 July 2011, London, UK

1 citations, July 2012 in “British Journal of Dermatology”

New treatments and management strategies for skin conditions like melanoma and Spitz naevi were discussed at the dermatologists' meeting.

Scientific Opinion on the Substantiation of a Health Claim Related to KF2BL20 and Maintenance of Normal Hair Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

research Scientific Opinion on the Substantiation of a Health Claim Related to KF2BL20 and Maintenance of Normal Hair Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

1 citations, July 2012 in “EFSA journal”

KF2BL20 does not have proven benefits for maintaining normal hair.

Therapeutic Effect of Nepenthes Kampotiana Lecomte Ethanol Extract on Androgenic Alopecia Through the Inhibition of Apoptosis and 5α-Reductase Activity

research Therapeutic Effect of Nepenthes Kampotiana Lecomte Ethanol Extract on Androgenic Alopecia Through the Inhibition of Apoptosis and 5α-Reductase Activity

July 2024 in “Natural Product Research”

Nk-EE may help treat hair loss by promoting hair growth and preventing hair follicle damage.

research Randomized Non-Inferiority Study of Oral Minoxidil (1.25 mg/day) vs. 5% Topical Minoxidil in Treating Female Pattern Hair Loss

January 2022

Oral minoxidil is as effective and safe as topical minoxidil for treating female pattern hair loss.

Comparative Study of Efficacy of Excimer Light Therapy vs. Intralesional Triamcinolone vs. Topical 5% Minoxidil for Alopecia Areata: An Observational Study

research Comparative Study of Efficacy of Excimer Light Therapy vs. Intralesional Triamcinolone vs. Topical 5% Minoxidil for Alopecia Areata: An Observational Study

January 2015 in “Przegla̧d dermatologiczny”

Intralesional triamcinolone is the most effective treatment for alopecia areata, followed by excimer light therapy, and then topical minoxidil. The scalp responds better to treatment than the beard area.

Scientific Opinion on the Substantiation of a Health Claim Related to Iron and Maintenance of Normal Hair Growth Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

research Scientific Opinion on the Substantiation of a Health Claim Related to Iron and Maintenance of Normal Hair Growth Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

March 2012 in “EFSA Journal”

Iron intake has not been proven to maintain normal hair growth.

Abstracts Presented at the 12th Joint Meeting of the International Society of Dermatopathology, March 4-5, 2009, Marines Memorial Club & Hotel, San Francisco, CA, USA

research Abstracts Presented at the 12th Joint Meeting of the International Society of Dermatopathology, March 4-5, 2009, Marines Memorial Club & Hotel, San Francisco, CA, USA

May 2009 in “The American Journal of Dermatopathology”

Mast cells play a significant role in hair loss conditions like male pattern hair loss and alopecia areata.

research 8th Annual Meeting of the European Society for Hair Restoration Surgery, Brussels, Belgium, June 2-5, 2005

July 2005 in “Hair transplant forum international”

research Construction of Research Utilization System of Human Tissues and Research Application: Study Using Human Tissues. Human Hair Follicle Regeneration Using Human Skin Tissues

January 2005 in “JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS”

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations, September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

5 citations, July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

The Free Communications of the Eighth Clinical Congress (Virtual) of the Gulf Chapter of the American Association of Clinical Endocrinologists; November 5–7, 2020

research The Free Communications of the Eighth Clinical Congress (Virtual) of the Gulf Chapter of the American Association of Clinical Endocrinologists; November 5–7, 2020

1 citations, December 2020 in “Journal of diabetes and endocrine practice”

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Scientific Opinion on the Substantiation of a Health Claim Related to Spermidine and Prolongation of the Growing Phase (Anagen) of the Hair Cycle Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

research Scientific Opinion on the Substantiation of a Health Claim Related to Spermidine and Prolongation of the Growing Phase (Anagen) of the Hair Cycle Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

1 citations, December 2011 in “EFSA Journal”

Spermidine may help extend the growth phase of hair.

Response to Comments on the Scientific Opinion on the Substantiation of a Health Claim Related to Spermidine and Prolongation of the Growing Phase (Anagen) of the Hair Cycle Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

research Response to Comments on the Scientific Opinion on the Substantiation of a Health Claim Related to Spermidine and Prolongation of the Growing Phase (Anagen) of the Hair Cycle Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

July 2012 in “EFSA supporting publications”

The EFSA maintained its view that spermidine's effect on hair growth is related to disease treatment and does not meet the health claim criteria.

research Co-Sponsored by the International Society of Hair Restoration Surgery: Live Surgery Workshop XI: Advancing the Industry of Hair Restoration, March 2–5, 2005, Orlando

March 2005 in “Hair transplant forum international”

Use of Urinary Bladder Matrix, a Bioactive, Acellular Scaffold Along with Platelet-Rich Plasma in Transplant Donor Scars and Androgenetic Alopecia: 5-Year Experience in Hair Duplication and Hair Loss Prevention/Non-Surgical Restoration

research Use of Urinary Bladder Matrix, a Bioactive, Acellular Scaffold Along with Platelet-Rich Plasma in Transplant Donor Scars and Androgenetic Alopecia: 5-Year Experience in Hair Duplication and Hair Loss Prevention/Non-Surgical Restoration

November 2013 in “Journal of clinical & experimental dermatology research”

Using urinary bladder matrix and platelet rich plasma can effectively treat transplant scars and prevent hair loss.

research A Double Blind, Randomised, Vehicle-Controlled, Safety and Tolerance Study of Topical PSK 3841 Solution at 5% Administered Twice Daily Over Four Weeks to Healthy Caucasian Males with Androgenetic Alopecia

December 2012 in “http://isrctn.org/>”

research A Multi-Centre, Double-Blind, Randomised, Vehicle-Controlled Study for a Quantitative Estimation of Hair Re-Growth in Male Subjects with Androgenetic Alopecia Treated Over 6 Months with Two Ethanolic PSK 3841 Solutions (2.5% and 5%)

December 2012 in “http://isrctn.org/>”

Scientific Opinion on the Substantiation of a Health Claim Related to a Combination of Thiamin, Riboflavin, Niacin, Pantothenic Acid, Pyridoxine, D-Biotin, and Pumpkin Seed Oil and Maintenance of Normal Hair Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

research Scientific Opinion on the Substantiation of a Health Claim Related to a Combination of Thiamin, Riboflavin, Niacin, Pantothenic Acid, Pyridoxine, D-Biotin, and Pumpkin Seed Oil and Maintenance of Normal Hair Pursuant to Article 13(5) of Regulation (EC) No 1924/2006

1 citations, July 2012 in “EFSA Journal”

The combination of certain vitamins and pumpkin seed oil has not been proven to maintain normal hair.

research The Association of Urolithiasis and Androgenetic Alopecia

January 2016 in “Renal Failure”

Kidney stones and hair loss are significantly related in people under 60 years old.

research 5α-Reductase Activity in the Prostate

237 citations, December 2001 in “Urology”

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

research Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review

117 citations, March 2013 in “Journal of the European Academy of Dermatology and Venereology”

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

research Topical Minoxidil for Hair Regrowth

80 citations, September 1984 in “Journal of The American Academy of Dermatology”

5% minoxidil helps hair regrowth in androgenic alopecia.

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