Administration of 45% Robusta Green Coffee Bean Ethanol Extract Solution and Its Effects on Hair Growth and 5α-Reductase Type 1 Levels in Male Wistar Rats

The study investigated the effects of a 45% robusta green coffee bean ethanol extract solution on hair growth and 5α-reductase type 1 levels in 30 male Wistar rats. The rats were divided into three groups and exposed to topical testosterone and different treatments for 21 days. The results showed no significant difference in hair length growth between the groups, with the group treated with the coffee bean extract showing a mean hair length of 8.24 ± 0.899%. However, the level of 5α-reductase type 1, an enzyme linked to hair loss, was significantly lower in the group treated with the coffee bean extract (467.61 ± 101.82%) compared to the control group (700.95 ± 197.67%). The study concluded that while the coffee bean extract did not significantly increase hair growth, it was effective in inhibiting the increase of 5α-reductase type 1 levels.