Long-Term Efficacy and Safety of Dutasteride in Korean Men With Androgenetic Alopecia: 5-Year Follow-Up Data

    September 2023 in “ Journal of The American Academy of Dermatology ”
    Jeehyun Lim, Seonghoon Choi, Soon Hyo Kwon, Woo‐Young Sim, Bark‐Lynn Lew
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    TLDR Dutasteride is safe and effective long-term for male hair loss.
    The study "Long-term efficacy and safety of dutasteride in Korean men with androgenetic alopecia: 5-year follow-up data exhibiting clinical improvement with sustained efficacy" investigated the 5-year efficacy and safety of dutasteride 0.5mg in 99 Korean men with androgenetic alopecia (AGA). After 5 years of treatment, 89.9% of patients showed improvement or prevention of disease progression, and 93.9% respectively. According to the basic and specific (BASP) classification, 52.5% of the basic type, 75% of the specific F type, and 83.3% of the specific V type showed improvement after 5 years of treatment with a decrease in the grades of the basic and/or specific type compared to baseline. The most common adverse events were sexual related symptoms within the first 6 months of the treatment period which subsided spontaneously. The study concluded that dutasteride exhibited long-term safety and efficacy in male AGA patients, with comparable outcomes to long-term studies evaluating the efficacy of finasteride in male AGA patients.
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