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COVID-19 might worsen symptoms and progression of benign prostatic hyperplasia, possibly due to inflammation and metabolic disturbances in the prostate gland. More research is needed to confirm this.

Using hair loss drugs finasteride and dutasteride may cause sexual side effects.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Dutasteride can stabilize hair loss in patients with frontal fibrosing alopecia, but its safety in women is unclear, so use it with caution.

The herbal hair gel could be a safe hair growth treatment with minimal side effects.

Methylated gene parts may cause finasteride-resistance in some enlarged prostate patients.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Herbs can potentially treat hair loss by inhibiting a key enzyme and promoting hair growth, and deficiencies in zinc, biotin, and iron are linked to hair loss.

Taking 5-alpha reductase inhibitors does not increase breast cancer risk in men.

The new particle system could be a promising treatment for diseases related to the 5-α reductase enzyme.

SHH protein helps nerve regeneration in hypertensive rats.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Methylation in specific gene region causes finasteride resistance in some BPH patients.

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.

Compounds from Angelica koreana roots, especially osthenol, could be effective for treating conditions like prostate disease and hair loss.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Early diagnosis and combination therapy, especially with finasteride and dutasteride, are key to managing Frontal Fibrosing Alopecia effectively.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Betula platyphylla extract, particularly the H3-2 fraction, may help treat hair loss by promoting cell growth and inhibiting a hair loss-related enzyme.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

Finasteride and dutasteride are effective for male hair loss and enlarged prostate but may cause reversible sexual side effects.

Finasteride may cause infertility in rats by affecting epididymis and sperm function.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

BRL 7660, once studied for male contraception, showed promise as an acne treatment but was not developed further due to competing drugs.

Finasteride changes antioxidant enzyme expression, possibly affecting sperm protection in rats.

Taking 5-alpha reductase inhibitors does not increase the risk of breast cancer in men.