Effectiveness of Dutasteride in a Large Series of Patients with Frontal Fibrosing Alopecia in Real Clinical Practice

    April 2021
    Aizuri Murad, Wilma F. Bergfeld
    Image of study
    TLDR Dutasteride can stabilize hair loss in patients with frontal fibrosing alopecia, but its safety in women is unclear, so use it with caution.
    The study titled "Effectiveness of dutasteride in a large series of patients with frontal fibrosing alopecia in real clinical practice" by Pindado-Ortega et al. examined the use of dutasteride, a 5-alpha-reductase inhibitor (5ARI), in the treatment of frontal fibrosing alopecia (FFA). The study found that dutasteride led to statistically significant disease stabilization in patients with FFA, particularly in the frontal and bilateral temporal aspects of the hairlines. The drug was well tolerated by the patients. The exact mechanism of action of 5ARI in FFA is not well understood, but it may help prevent hair miniaturization in androgen-sensitive scalp areas, leading to disease stabilization. However, the evidence for the effectiveness of 5ARI in FFA is limited to retrospective cohort studies, and the safety profile of the drug in women is still lacking. Therefore, caution should be exercised when prescribing dutasteride until more robust evidence is available. Nonetheless, dutasteride may be a beneficial treatment option for patients who cannot tolerate or have not responded to other systemic agents.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 9 months ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community 9 months on Fin - no progress , should I get on Dutasteride?

      in Chat  10 upvotes 1 month ago
      The user has been using finasteride, minoxidil, and nizoral for hair loss but hasn't seen regrowth, only maintenance. They are considering switching to dutasteride, which is believed to be more effective, but are concerned about potential side effects.

      community How essential is scalp biopsy when dealing with hair loss?

      in Treatment  6 upvotes 1 month ago
      The user experienced hair loss despite using Fin and Min for 12 years and switched to Dutasteride, RU58841, and Keto scalp serum, but shedding and itch persist. They are considering increasing Dutasteride to 2.5mg and questioning the necessity of a scalp biopsy, with mixed opinions on its usefulness.

    Related Research

    10 / 10 results