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Glossary 17α-estradiol

stereoisomer of estradiol studied for treating hair loss

17α-estradiol, also known as 17-alpha-estradiol, is a stereoisomer of the hormone estradiol. Unlike its more common counterpart, 17β-estradiol, 17α-estradiol has weaker estrogenic activity but has been studied for its potential benefits in treating conditions like androgenic alopecia (hair loss) due to its ability to modulate androgen metabolism.

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research 17α‐estradiol induces aromatase activity in intact human anagen hair follicles ex vivo

94 citations , August 2002 in “Experimental Dermatology”

This study found that 17α‐estradiol increases aromatase activity in female hair follicles, which may explain its beneficial effects in treating androgenetic alopecia.

research Lokaltherapie der Alopecia androgenetica mit 17α-Östradiol

54 citations , January 1980 in “Dermatology”

This study found that topical application of hair lotion containing 17α-estradiol may reduce androgenetic hair loss, as 63% of treated patients showed a decrease in telogen hairs compared to 37% in the control group.

research Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential

26 citations , February 2009 in “Drug Development Research”

This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.

The Efficacy and Safety of 17α-Estradiol (Ell-Cranell Alpha 0.025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comparative, Phase IV Study

research The Efficacy and Safety of 17α-Estradiol (Ell-Cranell® alpha 0.025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comparative, Phase IV Study

21 citations , January 2012 in “Annals of Dermatology”

This study reported that Ell-Cranell® alpha 0.025% solution significantly increased hair counts and diameter in Korean women with female pattern hair loss over an 8-month period, showing both efficacy and safety.

Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation

research Therapeutic Efficacy of a Combination Therapy of Topical 17α-Estradiol and Topical Minoxidil on Female Pattern Hair Loss: A Noncomparative, Retrospective Evaluation

6 citations , January 2017 in “Annals of Dermatology”

In this study, Korean women with female pattern hair loss who used a combination of topical 0.025% 17α-estradiol and 3% minoxidil saw significant increases in total hair count and hair caliber over six months.

research Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 Patients

4 citations , April 2020 in “Dermatology practical & conceptual”

This study reported that among postmenopausal women with female pattern hair loss, treatment with topical finasteride 0.5% and minoxidil 2% was more effective at improving hair condition than treatment with topical 17α-estradiol 0.05% and minoxidil 2%, particularly notable at 12-18 months of follow-up.

research Use of Topical Minoxidil, 17α-Estradiol and Hydrocortisone Butyrate in Frontal Fibrosing Alopecia

1 citations , May 2014 in “European Journal of Inflammation”

This study found that a topical lotion containing minoxidil, hydrocortisone butyrate, and 17α-estradiol improved or stabilized frontal fibrosing alopecia in 35 out of 40 women over 36 months.

research Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

In male mice and rats, this study found that 17α-estradiol improves metabolic health by acting through estrogen receptor α, suggesting a potential target for treating chronic diseases in male mammals.

research [Local therapy of androgenetic alopecia with 17 alpha-estradiol. A controlled, randomized double-blind study (author’s transl)].

37 citations , January 1980 in “PubMed”

This study found that topical hair lotions with 17 alpha-estradiol may reduce telogen hair loss in patients with androgenetic alopecia, though they did not lead to new hair regrowth.

research Effects of 17-β-Estradiol and ICI 182 780 on Hair Growth in Various Strains of Mice

32 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that the effectiveness of 17-beta-estradiol in inhibiting hair growth depends on its application method, and noted significant sex differences in response to 17-alpha-estradiol in male and female mice.

Compatibility of 17-α-Estradiol, Betamethasone, Finasteride, Melatonin, Prednicarbate, and Spironolactone in TrichoFoam: A Foaming Vehicle for Personalized Alopecia Treatments

research Compatibility of 17-α-Estradiol, Betamethasone, Finasteride, Melatonin, Prednicarbate, and Spironolactone in TrichoFoam™ - a Foaming Vehicle for Personalized Alopecia Treatments.

December 2024 in “PubMed”

This study evaluates the compatibility of six active pharmaceutical ingredients, including finasteride and spironolactone, with TrichoFoam™, a foam vehicle used in personalized treatments for alopecia, though it does not report specific results.

research Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles

January 2021 in “Figshare”

This study developed a nanostructured lipid carrier for 17-α-estradiol that showed stable physicochemical properties and improved targeting to hair follicles in alopecia treatment.

research Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles

January 2020 in “Journal of the Brazilian Chemical Society”

This study suggests that using nanostructured lipid carriers may improve the targeting of 17-α-estradiol in treating alopecia by improving skin penetration and stability.

research Peripubertal Testosterone, 17β-Estradiol and Progesterone Concentrations in Hair and Nails in Dobermann Dogs

July 2023 in “Animals”

This study found that hair and nails can effectively measure hormone changes such as testosterone, estrogen, and progesterone during the peripubertal period in dogs, with variations observed between males and females at specific developmental stages.

research Assessing tolerability and physiological responses to 17α-estradiol administration in male rhesus macaques

9 citations , March 2023 in “GeroScience”

research A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus)

1 citations , August 2024 in “GeroScience”

research Response to Javaheri et al., “Topical estrogens: Use in hair loss and additional safety concerns for consideration”

February 2026 in “Journal of the American Academy of Dermatology”

Estrogen is not recommended for menopausal hair loss due to insufficient evidence.

Efficacy and Safety of Combined Topical Ethinylestradiol with Minoxidil Versus Topical Minoxidil in Female Pattern Hair Loss: A Trichoscopic Randomized Controlled Clinical Study

research Efficacy and safety of combined topical ethinylestradiol with minoxidil versus topical minoxidil in female pattern hair loss. A trichoscopic randomized controlled clinical study

October 2024 in “Clinical and Experimental Dermatology”

This study found that combining 17α-estradiol 0.01% with minoxidil 2% offered no statistically significant advantage over minoxidil alone for treating female pattern hair loss and may increase the risk of menstrual irregularities.

Non-Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Revisited: An Update with a Special Focus on Adolescent and Adult Women

research Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women

117 citations , May 2017 in “Human Reproduction Update”

This review examines the epidemiology, pathophysiology, diagnosis, and management strategies for non-classic congenital hyperplasia due to 21-hydroxylase deficiency, and provides evidence-based recommendations for its treatment and genetic counseling.

research Serum AMH levels in the differential diagnosis of hyperandrogenemic conditions

9 citations , June 2014 in “European Journal of Obstetrics & Gynecology and Reproductive Biology”

Blood AMH levels are higher in women with PCOS than in those with other similar conditions.

research Clinical symptoms and sex steroid measurements in domestic ferrets (Mustela putorius furo) with hyperadrenocorticism

1 citations , December 2017 in “Research for Rural Development/Research for Rural Development (Online)”

This study found no correlation between clinical signs and sex steroid levels in ferrets with hyperadrenocorticism and noted that androstenedione was elevated in many cases.

research An estrogen receptor pathwayregulates thetelogen-anagen hair follicle transition andinfluences epidermal cell proliferation (epidermis/estrogen/keratinocyte/differentiation/mesenchymal

January 1996

This study found that estradiol affects hair growth in mice by regulating the transition of hair follicles from rest to growth phases via the estrogen receptor pathway in the dermal papilla.

17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells

research 17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells

18 citations , March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, 17β-estradiol increased VEGF production in differentiated THP-1 cells, while dihydrotestosterone counteracted this effect by modulating adenylate cyclase activity.

research New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-depth Review of the Literature

19 citations , December 2021 in “Endocrine Reviews”

This review highlights therapeutic options for inducing puberty in males and females with delayed puberty, emphasizing the need for larger trials to establish the best approaches.

Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase

5 citations , July 2021 in “Endocrinology, diabetes & metabolism”

This study found that glioblastoma cells express key enzymes involved in androgen synthesis, suggesting these enzymes might be potential targets for new therapeutic strategies.

research Metabolic study of androsta-1,4,6-triene-3,17-dione in horses using liquid chromatography/high resolution mass spectrometry

17 citations , August 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This study concluded that the best approach for detecting Androsta-1,4,6-triene-3,17-dione administration in horses is monitoring the metabolites M1b or M4 in urine, detectable up to 77 hours post-administration.

research Failure of Topical Estrogen Receptor Agonists and Antagonists to Alter Murine Hair Follicle Cycling

8 citations , January 1998 in “Journal of Investigative Dermatology”

This study did not find any significant effects of estradiol or its antagonists on hair growth in two common mouse strains, challenging previous results reported by Oh and Smart.

research On Photo-Stability of Oxybenzone

6 citations , January 1998 in “Journal of Investigative Dermatology”

This study found that oxybenzone is very stable under light exposure, contradicting previous findings of its oxidation to semiquinone after solar irradiation.

research MALE PSEUDOHERMAPHRODITISM DUE TO 17β-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY: STUDIES ON THE NATURAL HISTORY OF THE DEFECT AND EFFECT OF ANDROGENS ON GENDER ROLE

January 1983 in “Elsevier eBooks”

Masculinization in affected individuals occurs gradually after puberty due to hormone changes.

research Hirsutism and Virilization in the Female

2 citations , January 2013 in “Elsevier eBooks”

This chapter reviews the causes and underlying steroid pathways of hirsutism and virilization in women, detailing relevant conditions and laboratory assays without reporting new clinical results.