Efficacy and Safety of Combined Topical Ethinylestradiol with Minoxidil Versus Topical Minoxidil in Female Pattern Hair Loss: A Trichoscopic Randomized Controlled Clinical Study

October 2024 in “ Clinical and Experimental Dermatology ”

Nermeen Ibrahim Bedair, Mohamed H.M. El-Komy, Rania Mohamed, Rehab Nabil Shamma, Marwa Amer

ethinylestradiol minoxidil 17α-estradiol female pattern hair loss FPHL trichoscopic Rogaine

TLDR The combination treatment didn't work better than minoxidil alone and caused more menstrual issues.

This study investigated the efficacy and safety of a topical solution combining 17α-estradiol 0.01% with minoxidil 2% compared to minoxidil 2% alone in treating female pattern hair loss (FPHL) in 43 women over 6 months. Both treatment groups showed improvement, but the combination treatment did not provide a statistically significant advantage over minoxidil alone. Additionally, the combination treatment was associated with a higher incidence of menstrual irregularities. The study was limited by the small number of participants and the lack of cellular or molecular analysis of estradiol's effects.

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